T
Tak Ko
Researcher at Picower Institute for Learning and Memory
Publications - 7
Citations - 1369
Tak Ko is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Induced pluripotent stem cell & Transcriptome. The author has an hindex of 4, co-authored 5 publications receiving 775 citations.
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Journal ArticleDOI
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Yuan-Ta Lin,Jinsoo Seo,Jinsoo Seo,Fan Gao,Heather M. Feldman,Hsin-Lan Wen,Jay Penney,Jay Penney,Hugh P. Cam,Hugh P. Cam,Elizabeta Gjoneska,Elizabeta Gjoneska,Waseem K. Raja,Waseem K. Raja,Jemmie Cheng,Jemmie Cheng,Richard Rueda,Oleg Kritskiy,Fatema Abdurrob,Zhuyu Peng,Blerta Milo,Chung Jong Yu,Sara Elmsaouri,Dilip Dey,Tak Ko,Bruce A. Yankner,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: Consistently, converting APOE4 to APOE3 in brain cell types from sAD iPSCs was sufficient to attenuate multiple AD-related pathologies and establishes a reference for human cell-type-specific changes associated with theAPOE4 variant.
Journal ArticleDOI
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes
Waseem K. Raja,Alison E. Mungenast,Yuan-Ta Lin,Tak Ko,Fatema Abdurrob,Jinsoo Seo,Li-Huei Tsai +6 more
TL;DR: It is found that treatment of patient-derived organoids with β- and γ-secretase inhibitors significantly reduces amyloid and tau pathology and the potential of this model system to greatly increase the translatability of pre-clinical drug discovery in AD is shown.
Journal ArticleDOI
Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.
Joel W. Blanchard,Michael Bula,Michael Bula,Jose Davila-Velderrain,Leyla Anne Akay,Leyla Anne Akay,Lena Zhu,Lena Zhu,Alexander Frank,Alexander Frank,Matheus B. Victor,Matheus B. Victor,Julia Maeve Bonner,Julia Maeve Bonner,Hansruedi Mathys,Hansruedi Mathys,Hansruedi Mathys,Yuan-Ta Lin,Yuan-Ta Lin,Tak Ko,David A. Bennett,Hugh P. Cam,Hugh P. Cam,Manolis Kellis,Manolis Kellis,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: An iPSC-based three-dimensional model of the human blood–brain barrier reveals that NFAT and APOE dysregulation in pericyte-like mural cells contributes to cerebral amyloid angiopathy and can potentially be targeted to treat Alzheimer’s disease.
Journal ArticleDOI
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.
Jinsoo Seo,Jinsoo Seo,Oleg Kritskiy,L. Ashley Watson,L. Ashley Watson,Scarlett J. Barker,Scarlett J. Barker,Dilip Dey,Waseem K. Raja,Waseem K. Raja,Yuan-Ta Lin,Yuan-Ta Lin,Tak Ko,Sukhee Cho,Jay Penney,Jay Penney,M. Catarina Silva,Steven D. Sheridan,Diane Lucente,James F. Gusella,Bradford C. Dickerson,Stephen J. Haggarty,Li-Huei Tsai +22 more
TL;DR: A crucial role is demonstrated for p25/Cdk5 in mediating tau-associated pathology and inhibition of this kinase can remedy neurodegenerative processes in the presence of pathogenic tau mutation.
Journal ArticleDOI
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Joel W. Blanchard,Leyla Anne Akay,Jose Davila-Velderrain,Djuna von Maydell,Hansruedi Mathys,Shawn M. Davidson,Audrey H. Effenberger,Chih-Yu Chen,Kristal M. Maner-Smith,Ihab Hajjar,Eric A. Ortlund,Michael Bula,Emre Agbas,Ayesha P. Ng,Xueqiao Jiang,Martin Kahn,C Blanco-Duque,Nicolas Lavoie,Liwang Liu,Ricardo Reyes,Yuan-Ta Lin,Tak Ko,Lea R'Bibo,William T. Ralvenius,David A. Bennett,Hugh P. Cam,Manolis Kellis,Li-Huei Tsai +27 more
TL;DR: In this article , a single-cell transcriptomics profiling of post-mortem human brains from APOE4 carriers compared with non-carriers was performed to gain more comprehensive insights into the impact of APOE-4 on the human brain.