J
Joh-E Ikeda
Researcher at Tokai University
Publications - 11
Citations - 1395
Joh-E Ikeda is an academic researcher from Tokai University. The author has contributed to research in topics: Gene & Cyclin-dependent kinase. The author has an hindex of 10, co-authored 11 publications receiving 1352 citations. Previous affiliations of Joh-E Ikeda include University of Ottawa.
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Journal ArticleDOI
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Shinji Hadano,Collette K. Hand,Hitoshi Osuga,Yoshiko Yanagisawa,Asako Otomo,Rebecca S. Devon,Natsuki Miyamoto,Junko Showguchi-Miyata,Yoshinori Okada,Roshni R. Singaraja,Denise A. Figlewicz,Thomas J. Kwiatkowski,Betsy A. Hosler,Tally Lerman Sagie,Jennifer Skaug,Jamal Nasir,Jamal Nasir,Robert H. Brown,Stephen W. Scherer,Guy A. Rouleau,Michael R. Hayden,Joh-E Ikeda,Joh-E Ikeda +22 more
TL;DR: Two independent deletion mutations linked to ALS2 are identified in the coding exons of the new gene ALS2, providing strong evidence that ALS2 is the causative gene underlying this form of ALS.
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Cyclin-dependent kinases as a therapeutic target for stroke
Hitoshi Osuga,Sachiko Osuga,Fuhu Wang,Raouf Fetni,Matthew J. Hogan,Ruth S. Slack,Antoine M. Hakim,Joh-E Ikeda,David S. Park +8 more
TL;DR: Results indicate that CDKs are an important therapeutic target for the treatment of reperfusion injury after ischemia and Administration of a CDK inhibitor blocks pRb phosphorylation and the increase in E2F1 levels and dramatically reduces neuronal death by 80%.
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Molecular characterization and cytological mapping of a non-repetitive DNA sequence region from the W chromosome of chicken and its use as a universal probe for sexing Carinatae birds
Akira Ogawa,Irina Solovei,Nancy Hutchison,Yasushi Saitoh,Joh-E Ikeda,Herbert C. Macgregor,Shigeki Mizuno +6 more
TL;DR: A non-repetitive genomic DNA region of about 25 kb was cloned from the W chromosome of chicken using a genomic library prepared from a single W chromosomes of the chicken.
Journal ArticleDOI
Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance after Global Ischemia in the Rat
Fuhu Wang,Dale Corbett,Hitoshi Osuga,Sachiko Osuga,Joh-E Ikeda,Ruth S. Slack,Matthew J. Hogan,Antoine M. Hakim,David S. Park +8 more
TL;DR: Results indicate that cyclin-dependent kinase inhibition provides an extended period of morphologic and functional neuroprotection that may allow time for other neuroprotective modalities to be introduced.
Journal ArticleDOI
Production of transgenic miniature pigs by pronuclear microinjection.
Masaki Uchida,Yoshiki Shimatsu,Kyuichiro Onoe,Noriko Matsuyama,Rikio Niki,Joh-E Ikeda,Hiroshi Imai +6 more
TL;DR: The huntingtin gene cloned from miniature pig, which is a homologue of candidate gene for Huntington's disease, connected with rat neuron-specific enolase promoter region, was injected into a pronucleus of fertilized eggs with micromanipulator in the first successful report concerning the production of transgenic miniature pig by pronuclear microinjection.