R
Rebecca S. Devon
Researcher at University of British Columbia
Publications - 35
Citations - 4004
Rebecca S. Devon is an academic researcher from University of British Columbia. The author has contributed to research in topics: Gene & Chromosomal translocation. The author has an hindex of 22, co-authored 33 publications receiving 3875 citations. Previous affiliations of Rebecca S. Devon include Western General Hospital & University of Edinburgh.
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Journal ArticleDOI
Disruption of two novel genes by a translocation co-segregating with schizophrenia
J. Kirsty Millar,Julie C. Wilson-Annan,Susan Anderson,Sheila Christie,Martin S. Taylor,Collin A.M. Semple,Rebecca S. Devon,David St Clair,Walter J. Muir,Douglas Blackwood,David J. Porteous +10 more
TL;DR: Observations indicate that DISC1 and DISC2 should be considered formal candidate genes for susceptibility to psychiatric illness.
Journal ArticleDOI
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Shinji Hadano,Collette K. Hand,Hitoshi Osuga,Yoshiko Yanagisawa,Asako Otomo,Rebecca S. Devon,Natsuki Miyamoto,Junko Showguchi-Miyata,Yoshinori Okada,Roshni R. Singaraja,Denise A. Figlewicz,Thomas J. Kwiatkowski,Betsy A. Hosler,Tally Lerman Sagie,Jennifer Skaug,Jamal Nasir,Jamal Nasir,Robert H. Brown,Stephen W. Scherer,Guy A. Rouleau,Michael R. Hayden,Joh-E Ikeda,Joh-E Ikeda +22 more
TL;DR: Two independent deletion mutations linked to ALS2 are identified in the coding exons of the new gene ALS2, providing strong evidence that ALS2 is the causative gene underlying this form of ALS.
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Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
Elizabeth J. Slow,Rona K. Graham,Alexander P. Osmand,Rebecca S. Devon,Ge Lu,Yu Deng,Jacqui Pearson,Kuljeet Vaid,Nagat Bissada,Ronald Wetzel,Blair R. Leavitt,Michael R. Hayden +11 more
TL;DR: The shortstop mouse is protected from excitotoxicity, providing in vivo evidence suggesting that neurodegeneration in Huntington disease is mediated by excitOToxic mechanisms.
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Splinkerettes—improved vectorettes for greater efficiency in PCR walking
TL;DR: End-repair priming involves the free cohesive ends of unligated vectorettes and inserts which are based on restriction sites that produce 5' overhangs and will not be amplified in the PCR because the two halves will form a stable hairpin structure which will be refractory to amplification.
Journal ArticleDOI
Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia.
J K Millar,Sheila Christie,Susan Anderson,D. Lawson,D Hsiao-Wei Loh,Rebecca S. Devon,Benoit Arveiler,Walter J. Muir,Walter J. Muir,D. H. R. Blackwood,D. H. R. Blackwood,David J. Porteous +11 more
TL;DR: A contiguous clone map of PACs and cosmids extending across at least 400 kb of the chromosome 1 translocation breakpoint region has provided the basis for examination of the genomic structure of DISC1, a candidate gene potentially involved in the aetiology of major psychiatric illness.