J
Johan Staaf
Researcher at Lund University
Publications - 179
Citations - 10039
Johan Staaf is an academic researcher from Lund University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 46, co-authored 153 publications receiving 8416 citations. Previous affiliations of Johan Staaf include University College Cork.
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Journal ArticleDOI
Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization.
Göran Jönsson,Tara L. Naylor,Johan Vallon-Christersson,Johan Staaf,Jia Huang,M. Renee Ward,Joel Greshock,Lena Luts,Håkan Olsson,Nazneen Rahman,Michael R. Stratton,Markus Ringnér,Åke Borg,Barbara L. Weber +13 more
TL;DR: Using a set of 169 BAC clones that detect significantly different frequencies of copy number changes in inherited and sporadic tumors, these could be discriminated into separate groups using hierarchical clustering and several candidate genes affected by up- or down-regulation were identified.
Journal ArticleDOI
Integrated genomic and gene expression profiling identifies two major genomic circuits in urothelial carcinoma.
David Lindgren,Gottfrid Sjödahl,Martin Lauss,Johan Staaf,Gunilla Chebil,Kristina Lövgren,Sigurdur Gudjonsson,Fredrik Liedberg,Oliver Patschan,Wiking Månsson,Mårten Fernö,Mattias Höglund +11 more
TL;DR: The integrative approach revealed at least two separate networks of genomic alterations linked to the molecular diversity seen in UC, and that these circuits may reflect distinct pathways of tumor development.
Journal ArticleDOI
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study.
Johan Staaf,Dominik Glodzik,Dominik Glodzik,Dominik Glodzik,Ana Bosch,Johan Vallon-Christersson,Christel Reuterswärd,Jari Häkkinen,Andrea Degasperi,Andrea Degasperi,Tauanne Dias Amarante,Tauanne Dias Amarante,Lao H. Saal,Cecilia Hegardt,Hilary Stobart,Anna Ehinger,Christer Larsson,Lisa Rydén,Niklas Loman,Martin Malmberg,Anders Kvist,Hans Ehrencrona,Helen Davies,Helen Davies,Åke Borg,Serena Nik-Zainal +25 more
TL;DR: Whole-genome sequencing in triple-negative breast cancer supports the prognostic value of the HRDetect mutational-signature-based algorithm for improving patient stratification in a real-world, population-based clinical diagnostic setting.
Journal ArticleDOI
Identification of Subtypes in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Reveals a Gene Signature Prognostic of Outcome
Johan Staaf,Markus Ringnér,Johan Vallon-Christersson,Göran Jönsson,Pär-Ola Bendahl,Karolina Holm,Adalgeir Arason,Haukur Gunnarsson,Cecilia Hegardt,Bjarni A. Agnarsson,Lena Luts,Dorthe Grabau,Mårten Fernö,P Malmström,Oskar T. Johannsson,Niklas Loman,Rosa B. Barkardottir,Åke Borg +17 more
TL;DR: The Her2-derived prognostic predictor provides further insight into the heterogeneous biology of HER2-positive tumors and may become useful for improved selection of patients who need additional treatment with new drugs targeting the HER2 pathway.
Journal ArticleDOI
Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
Johan Staaf,David Lindgren,Johan Vallon-Christersson,Anders Isaksson,Hanna Göransson,Gunnar Juliusson,Richard Rosenquist,Mattias Höglund,Åke Borg,Markus Ringnér +9 more
TL;DR: A high sensitivity and specificity of the strategy for detecting both minute and gross allelic imbalances in heterogeneous tumor samples is demonstrated.