S
Sigurdur Gudjonsson
Researcher at Lund University
Publications - 73
Citations - 5071
Sigurdur Gudjonsson is an academic researcher from Lund University. The author has contributed to research in topics: Bladder cancer & Cystectomy. The author has an hindex of 25, co-authored 68 publications receiving 4375 citations. Previous affiliations of Sigurdur Gudjonsson include University of Iceland.
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Journal ArticleDOI
Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6C hi monocyte precursors
Calum C. Bain,Charlotte L. Scott,Heli Uronen-Hansson,Sigurdur Gudjonsson,O. Jansson,Olof Grip,Martin Guilliams,Martin Guilliams,Bernard Malissen,William W. Agace,A. Mc I. Mowat +10 more
TL;DR: Phenotypic analysis of human intestinal mφ indicates that analogous processes occur in the normal and Crohn's disease ileum, and shows for the first time that resident and inflammatory m φ in the intestine represent alternative differentiation outcomes of the same precursor.
Journal ArticleDOI
A Molecular Taxonomy for Urothelial Carcinoma
Gottfrid Sjödahl,Martin Lauss,Kristina Lövgren,Gunilla Chebil,Sigurdur Gudjonsson,Srinivas Veerla,Oliver Patschan,Mattias Aine,Mårten Fernö,Markus Ringnér,Wiking Månsson,Fredrik Liedberg,David Lindgren,Mattias Höglund +13 more
TL;DR: The molecular subtypes cut across pathologic classification, and class-defining gene signatures show coordinated expression irrespective of pathologic stage and grade, suggesting the molecular phenotypes as intrinsic properties of the tumors.
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IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation.
Emma Persson,Heli Uronen-Hansson,Monika Semmrich,Aymeric Rivollier,Karin Hägerbrand,Jan Marsal,Sigurdur Gudjonsson,Ulf Håkansson,Boris Reizis,Knut Kotarsky,William W. Agace,William W. Agace +11 more
TL;DR: It is demonstrated that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4), and results suggest a central role for IRF4-dependent, IL-6 producing CD103 (+) CD11b (+) DCs in intestinal Th17 cell differentiation.
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Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa–pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation?
Richard Sylvester,Willem Oosterlinck,Sten Holmäng,Matthew R. Sydes,Alison Birtle,Sigurdur Gudjonsson,Cosimo De Nunzio,Kikuo Okamura,Eero Kaasinen,Eduardo Solsona,Bedeir Ali-El-Dein,Can Ali Tatar,Brant A. Inman,James N'Dow,Jorg R. Oddens,Marek Babjuk +15 more
TL;DR: A single instillation of chemotherapy immediately after resection reduces the risk of recurrence in non-muscle-invasive bladder cancer; however, it should not be given to patients at high risk of Recurrence due to its lack of efficacy in this subgroup.
Journal ArticleDOI
Combined gene expression and genomic profiling define two intrinsic molecular subtypes of urothelial carcinoma and gene signatures for molecular grading and outcome.
David Lindgren,Attila Frigyesi,Sigurdur Gudjonsson,Gottfrid Sjödahl,Christer Halldén,Gunilla Chebil,Srinivas Veerla,Tobias Rydén,Wiking Månsson,Fredrik Liedberg,Mattias Höglund +10 more
TL;DR: The combination of molecular and histopathologic classification systems might provide a strong improvement for bladder cancer classification and produce new insights into the development of this tumor type.