J
Johannes-Matthias Löhr
Researcher at Karolinska University Hospital
Publications - 19
Citations - 677
Johannes-Matthias Löhr is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Pancreatitis & Pancreatic cancer. The author has an hindex of 11, co-authored 19 publications receiving 491 citations. Previous affiliations of Johannes-Matthias Löhr include Karolinska Institutet.
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Journal ArticleDOI
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.
Elisabeth Hessmann,Melanie S. Patzak,Lukas Klein,Nai-Ming Chen,Vijayalakshmi Kari,Iswarya Ramu,Tashinga E. Bapiro,Tashinga E. Bapiro,Kristopher K. Frese,Aarthi Gopinathan,Frances M. Richards,Duncan I. Jodrell,Caroline S. Verbeke,Caroline S. Verbeke,Xuan Li,Rainer Heuchel,Johannes-Matthias Löhr,Steven A. Johnsen,Thomas M. Gress,Volker Ellenrieder,Albrecht Neesse +20 more
TL;DR: It is suggested that fibroblast drug scavenging may contribute to the clinical failure of gemcitabine in desmoplastic PDAC and metabolic targeting of CAFs may be a promising strategy to enhance the antiproliferative effects of gem citabine.
Journal ArticleDOI
Cationic liposomal paclitaxel plus gemcitabine or gemcitabine alone in patients with advanced pancreatic cancer: a randomized controlled phase II trial
Johannes-Matthias Löhr,Stephan L. Haas,Wolf O. Bechstein,György Bodoky,K. Cwiertka,Wolfgang Fischbach,U. R. Fölsch,Dieter Jäger,D. Osinsky,J. Prausova,W. E. Schmidt,Manfred P. Lutz +11 more
TL;DR: Treatment of advanced PDAC with GEM + ET showed beneficial survival and efficacy and a randomized phase III trial should confirm this positive trend.
Journal ArticleDOI
The ageing pancreas: a systematic review of the evidence and analysis of the consequences.
Johannes-Matthias Löhr,Johannes-Matthias Löhr,N. Panic,Miroslav Vujasinovic,Caroline S. Verbeke +4 more
TL;DR: Therapeutic intervention, which may consist of supplementation of pancreatic enzymes and/or vitamins in aged individuals with proven exocrine pancreas insufficiency, could contribute to healthy ageing.
Journal ArticleDOI
Alcohol consumption and digestive tract cancer.
TL;DR: Alcohol overconsumption is a serious avoidable risk factor for the development of gastrointestinal tract cancer, both alone but even more in combination with other risk factors such as tobacco and obesity.
Journal ArticleDOI
Properties of different pancreatin preparations used in pancreatic exocrine insufficiency.
Johannes-Matthias Löhr,Frank Hummel,Konstantinos T. Pirilis,Gregor Steinkamp,Andreas Körner,Friederike Henniges +5 more
TL;DR: Although all pancreatin preparations contain the declared lipase units and are acid-stable, a wide variation was observed in the particle size, surface, acid resistance, release of enzymes, pharmacokinetics and batch consistency.