J
Johannes Sitterberg
Researcher at University of Marburg
Publications - 20
Citations - 1803
Johannes Sitterberg is an academic researcher from University of Marburg. The author has contributed to research in topics: Nanoparticle & Drug carrier. The author has an hindex of 14, co-authored 20 publications receiving 1694 citations. Previous affiliations of Johannes Sitterberg include Shenyang Pharmaceutical University.
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Journal ArticleDOI
Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes
Shirui Mao,Michael Neu,Oliver Germershaus,Olivia M. Merkel,Johannes Sitterberg,Udo Bakowsky,Thomas Kissel +6 more
TL;DR: Both the chain length and graft density of PEG were found to strongly influence siRNA condensation and stability and hence affect the knockdown efficiency of PEI-PEG/siRNA polyplexes.
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Design of Estradiol Loaded PLGA Nanoparticulate Formulations: A Potential Oral Delivery System for Hormone Therapy
TL;DR: DMAB stabilized PLGA nanoparticles have great potential as carriers for oral delivery of estradiol, and Histopathological examination and blood counts indicated the absence of inflammatory response.
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Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structure-activity relationships in vitro.
TL;DR: PEGylation led to improved colloidal stability of polyplexes and significantly increased cellular uptake and transfection efficiency in NIH/3T3, L929 and MeWo cells compared to trimethyl chitosan, highlighting the importance of investigating polyplex stability under different pH- and ionic strength conditions.
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Utilising atomic force microscopy for the characterisation of nanoscale drug delivery systems.
TL;DR: Nanomedical research is increasingly focused on the design, characterisation and delivery of nano-sized drug carriers such as nanoparticles, liposomes and polyplexes, and this review aims to highlight the scope and advantages of atomic force microscopy in this area.
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Peroral delivery of insulin using chitosan derivatives: a comparative study of polyelectrolyte nanocomplexes and nanoparticles.
Anchalee Jintapattanakit,Varaporn Buraphacheep Junyaprasert,Shirui Mao,Shirui Mao,Johannes Sitterberg,Udo Bakowsky,Thomas Kissel +6 more
TL;DR: Stable, uniform, and spherical PEC/NP with high insulin association efficiency (AE) were formed at or close to optimized polymer/insulin (+/-) charge ratio, depending on polymer structure.