J
John A. D'Orazio
Researcher at University of Kentucky
Publications - 78
Citations - 4297
John A. D'Orazio is an academic researcher from University of Kentucky. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 21, co-authored 72 publications receiving 3465 citations. Previous affiliations of John A. D'Orazio include Harvard University & Markey Cancer Center.
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Journal ArticleDOI
UV Radiation and the Skin
TL;DR: Developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance are targeted.
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Central Role of p53 in the Suntan Response and Pathologic Hyperpigmentation
Rutao Cui,Hans R. Widlund,Erez Feige,Jennifer Y. Lin,Dara L. Wilensky,Viven E. Igras,John A. D'Orazio,Claire Y. Fung,Carl F. Schanbacher,Scott R. Granter,Scott R. Granter,David E. Fisher +11 more
TL;DR: In this paper, the authors provided biochemical and genetic evidence demonstrating that UV induction of POMC/MSH in skin is directly controlled by p53 and that absence of p53, as in knockout mice, is associated with absence of the UV-tanning response.
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Resveratrol and cancer: focus on in vivo evidence
TL;DR: This review highlights the in vivo effects of resveratrol treatment on breast, colorectal, liver, pancreatic, and prostate cancers and suggests that many factors need to be considered before resver atrol can be used for human cancer prevention or therapy.
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An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background
Devarati Mitra,Xi Luo,Ann M. Morgan,Jin Wang,Mai P. Hoang,Jennifer A. Lo,Candace R. Guerrero,Jochen K. Lennerz,Martin C. Mihm,Jennifer A. Wargo,Kathleen C. Robinson,Suprabha P. Devi,Jillian C. Vanover,John A. D'Orazio,Martin McMahon,Marcus Bosenberg,Kevin M. Haigis,Daniel A. Haber,Yinsheng Wang,David E. Fisher +19 more
TL;DR: The data suggest that the pheomelanin pigment pathway produces ultraviolet-radiation-independent carcinogenic contributions to melanomagenesis by a mechanism of oxidative damage, which suggests protection from ultraviolet radiation remains important, and additional strategies may be required for optimal melanoma prevention.
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Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
John A. D'Orazio,Tetsuji Nobuhisa,Tetsuji Nobuhisa,Rutao Cui,Rutao Cui,Michelle Arya,Michelle Arya,Malinda Spry,Kazumasa Wakamatsu,Vivien Igras,Vivien Igras,Takahiro Kunisada,Scott R. Granter,Emi K. Nishimura,Shosuke Ito,David E. Fisher,David E. Fisher +16 more
TL;DR: It is shown that ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blonde-haired Mc1re/e mice, and a clinical strategy for topical small-molecule manipulation of pigmentation is suggested.