M
Mai P. Hoang
Researcher at Harvard University
Publications - 210
Citations - 7585
Mai P. Hoang is an academic researcher from Harvard University. The author has contributed to research in topics: Melanoma & Carcinoma. The author has an hindex of 45, co-authored 199 publications receiving 6487 citations. Previous affiliations of Mai P. Hoang include University of Texas MD Anderson Cancer Center & Boston University.
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Journal ArticleDOI
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Priscilla K. Brastianos,Scott L. Carter,Scott L. Carter,Sandro Santagata,Sandro Santagata,Daniel P. Cahill,Amaro Taylor-Weiner,Robert T. Jones,Eliezer M. Van Allen,Eliezer M. Van Allen,Michael S. Lawrence,Peleg M. Horowitz,Kristian Cibulskis,Keith L. Ligon,Keith L. Ligon,Josep Tabernero,Joan Seoane,Elena Martínez-Sáez,William T. Curry,Ian F. Dunn,Sun Ha Paek,Sung Hye Park,Aaron McKenna,Aaron Chevalier,Mara Rosenberg,Fred G. Barker,Corey M. Gill,Paul Van Hummelen,Aaron R. Thorner,Bruce E. Johnson,Mai P. Hoang,Toni K. Choueiri,Sabina Signoretti,Carrie Sougnez,Michael S. Rabin,Nan Lin,Eric P. Winer,Anat Stemmer-Rachamimov,Matthew Meyerson,Levi A. Garraway,Levi A. Garraway,Stacey Gabriel,Eric S. Lander,Rameen Beroukhim,Rameen Beroukhim,Tracy T. Batchelor,José Baselga,David N. Louis,Gad Getz,Gad Getz,William C. Hahn,William C. Hahn +51 more
TL;DR: Stricker et al. as discussed by the authors performed whole-exome sequencing of 86 matched brain metastases, primary tumors, and normal tissue and found potentially clinically informative alterations in the brain metastasis not detected in the matched primary-tumor sample.
Journal ArticleDOI
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background
Devarati Mitra,Xi Luo,Ann M. Morgan,Jin Wang,Mai P. Hoang,Jennifer A. Lo,Candace R. Guerrero,Jochen K. Lennerz,Martin C. Mihm,Jennifer A. Wargo,Kathleen C. Robinson,Suprabha P. Devi,Jillian C. Vanover,John A. D'Orazio,Martin McMahon,Marcus Bosenberg,Kevin M. Haigis,Daniel A. Haber,Yinsheng Wang,David E. Fisher +19 more
TL;DR: The data suggest that the pheomelanin pigment pathway produces ultraviolet-radiation-independent carcinogenic contributions to melanomagenesis by a mechanism of oxidative damage, which suggests protection from ultraviolet radiation remains important, and additional strategies may be required for optimal melanoma prevention.
Journal ArticleDOI
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas
Priscilla K. Brastianos,Amaro Taylor-Weiner,Peter E. Manley,Robert T. Jones,Dora Dias-Santagata,Aaron R. Thorner,Michael S. Lawrence,Fausto J. Rodriguez,Lindsay A. Bernardo,Laura Schubert,Ashwini Sunkavalli,Nick Shillingford,Monica L. Calicchio,Hart G.W. Lidov,Hala Taha,Maria Martinez-Lage,Mariarita Santi,Phillip B. Storm,John Y K Lee,James N. Palmer,Nithin D. Adappa,R. Michael Scott,Ian F. Dunn,Edward R. Laws,Chip Stewart,Keith L. Ligon,Mai P. Hoang,Paul Van Hummelen,William C. Hahn,David N. Louis,Adam C. Resnick,Mark W. Kieran,Gad Getz,Sandro Santagata +33 more
TL;DR: Using whole-exome sequencing, mutations in CTNNB1 (β-catenin) and BRAF were identified in nearly all adamantinomatous and papillary craniopharyngiomas examined and clonal in each tumor subtype, and these findings have important implications for the diagnosis and treatment of these neoplasms.
Journal ArticleDOI
Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
Russell W. Jenkins,Amir Reza Aref,Patrick H. Lizotte,Elena Ivanova,Susanna Stinson,Chensheng W. Zhou,Michaela Bowden,Jiehui Deng,Hongye Liu,Diana Miao,Diana Miao,Meng Xiao He,Meng Xiao He,William F. Walker,Gao Zhang,Tian Tian,Chaoran Cheng,Zhi Wei,Sangeetha Palakurthi,Mark A. Bittinger,Hans Vitzthum,Jong Wook Kim,Jong Wook Kim,Ashley A. Merlino,Max M. Quinn,Chandrasekar Venkataramani,Joshua A. Kaplan,Andrew Portell,Prafulla C. Gokhale,Bart Phillips,Alicia Smart,Alicia Smart,Asaf Rotem,Robert E. Jones,Lauren Keogh,Maria Anguiano,Lance Stapleton,Zhiheng Jia,Michal Barzily-Rokni,Israel Cañadas,Tran C. Thai,Marc R. Hammond,Raven Vlahos,Eric S. Wang,Hua Zhang,Shuai Li,Glenn J. Hanna,Wei Huang,Mai P. Hoang,Adriano Piris,Jean Pierre Eliane,Anat Stemmer-Rachamimov,Lisa A. Cameron,Mei-Ju Su,Parin Shah,Benjamin Izar,Benjamin Izar,Manisha Thakuria,Manisha Thakuria,Nicole R. LeBoeuf,Nicole R. LeBoeuf,Guilherme Rabinowits,Viswanath Gunda,Sareh Parangi,James M. Cleary,Brian C. Miller,Shunsuke Kitajima,Rohit Thummalapalli,Benchun Miao,Thanh U. Barbie,Vivek Sivathanu,Joshua A. Wong,William G. Richards,Raphael Bueno,Charles H. Yoon,Juan J. Miret,Meenhard Herlyn,Levi A. Garraway,Eliezer M. Van Allen,Eliezer M. Van Allen,Gordon J. Freeman,Paul Kirschmeier,Jochen H. Lorch,Patrick A. Ott,F. Stephen Hodi,Keith T. Flaherty,Roger D. Kamm,Genevieve M. Boland,Kwok-Kin Wong,David Dornan,Cloud P. Paweletz,David A. Barbie +91 more
TL;DR: The ability to interrogate ex vivo response to PD-1 blockade using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS) is demonstrated, which represents a novel platform to evaluate ICB using established murine models as well as clinically relevant patient specimens.
A Report of 2 Cases
TL;DR: Findings from the histologic and immunohistochemical findings of 2 cases of intratubular embryonal carcinoma are strongly supportive of the opinion that intratUBular embryonic carcinoma is the precursor of invasive embryonal cancer.