J
John A. Heddle
Researcher at York University
Publications - 118
Citations - 7753
John A. Heddle is an academic researcher from York University. The author has contributed to research in topics: Micronucleus test & Mutant. The author has an hindex of 38, co-authored 118 publications receiving 7579 citations. Previous affiliations of John A. Heddle include Keele University & Lawrence Livermore National Laboratory.
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Journal ArticleDOI
A rapid in vivo test for chromosomal damage
TL;DR: An in vivo method for screening drugs, food additives, and other chemicals that might cause chromosomal aberrations has been tested and is reliable, easy, and very much more rapid than the traditional method.
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The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes.
TL;DR: The micronucleus assay reflects the aberration frequencies so well and is so fast, it is suitable for a rapid assessment of chromosomal damage.
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The induction of micronuclei as a measure of genotoxicity: A report of the U.S. environmental protection agency Gene-Tox program☆
John A. Heddle,Mark Hite,Barbara Kirkhart,Kathleen H. Mavournin,James T. MacGregor,Gordon W. Newell,Michael F. Salamone +6 more
TL;DR: The most important recommendations in this report are: (1) at least 500 PCE should be examined from each of 8 animals to detect an increase of about 4‰ (per thousand) PCE when the background is less than 4 per 1000, and (2) the highest possible doses should be used.
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Micronuclei as an index of cytogenetic damage: Past, present, and future
John A. Heddle,Michael C. Cimino,M. Hayashi,F. Romagna,Michael D. Shelby,James D. Tucker,Ph. Vanparys,James T. MacGregor +7 more
TL;DR: After the workshop an effort was made to determine what single protocol would satisfy the requirements set for the micronucleus test by as many regulatory agencies as possible, including the requirements of six regulatory authorities in Canada, the European Economic Community, the Organization for Economic Co‐operation and Development, Japan, and the United States.
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The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program
TL;DR: The protocol recommended for the micronucleus assay in mammalian bone marrow has been revised and simplified and the minimum number of cells to be scored per treatment group has been increased to 20,000 to increase the ability of the assay to detect a doubling of the control micron nucleus frequency.