J
John A. Lees
Researcher at Imperial College London
Publications - 99
Citations - 4618
John A. Lees is an academic researcher from Imperial College London. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 29, co-authored 85 publications receiving 2410 citations. Previous affiliations of John A. Lees include New York University & Wellcome Trust Sanger Institute.
Papers
More filters
Journal ArticleDOI
Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: a modelling study.
Alexandra B. Hogan,Britta L Jewell,Ellie Sherrard-Smith,Juan F. Vesga,Oliver J Watson,Charles Whittaker,Arran Hamlet,Jennifer A. Smith,Peter Winskill,Robert Verity,Marc Baguelin,John A. Lees,Lilith K Whittles,Kylie E. C. Ainslie,Samir Bhatt,A Boonyasiri,Nicholas F Brazeau,Lorenzo Cattarino,Laura V Cooper,Helen Coupland,Gina Cuomo-Dannenburg,Amy Dighe,Bimandra A Djaafara,Christl A. Donnelly,Christl A. Donnelly,Jeff Eaton,Sabine L. van Elsland,Richard G. FitzJohn,Han Fu,Katy A. M. Gaythorpe,William Green,D Haw,Sarah Hayes,Wes Hinsley,Natsuko Imai,Daniel J Laydon,Tara D. Mangal,Thomas A. Mellan,Swapnil Mishra,Gemma Nedjati-Gilani,Kris V Parag,Hayley A Thompson,H. Juliette T. Unwin,Michaela A. C. Vollmer,Caroline E. Walters,Haowei Wang,Y Wang,Xiaoyue Xi,Neil M. Ferguson,Lucy C Okell,Thomas S. Churcher,Nimalan Arinaminpathy,Azra C. Ghani,Patrick G T Walker,Timothy B. Hallett +54 more
TL;DR: The extent to which disruptions to services for HIV, tuberculosis, and malaria in low-income and middle-income countries with high burdens of these diseases could lead to additional loss of life over the next 5 years was quantified.
Journal ArticleDOI
Reduction in mobility and COVID-19 transmission.
Pierre Nouvellet,Pierre Nouvellet,Sangeeta N. Bhatia,Anne Cori,Kylie E. C. Ainslie,Marc Baguelin,Samir Bhatt,Adhiratha Boonyasiri,Nicholas F Brazeau,Lorenzo Cattarino,Laura V Cooper,Helen Coupland,Zulma M. Cucunubá,Gina Cuomo-Dannenburg,Amy Dighe,Bimandra A Djaafara,Ilaria Dorigatti,Oliver Eales,Sabine L. van Elsland,Fabrícia F. Nascimento,Richard G. FitzJohn,Katy A. M. Gaythorpe,Lily Geidelberg,William Green,Arran Hamlet,Katharina Hauck,Wes Hinsley,Natsuko Imai,B Jeffrey,Edward Knock,Daniel J Laydon,John A. Lees,Tara D. Mangal,Thomas A. Mellan,Gemma Nedjati-Gilani,Kris V Parag,Margarita Pons-Salort,Manon Ragonnet-Cronin,Steven Riley,H. Juliette T. Unwin,Robert Verity,Michaela A. C. Vollmer,Erik M. Volz,Patrick G T Walker,Caroline E. Walters,Haowei Wang,Oliver J Watson,Charles Whittaker,Lilith K Whittles,Xiaoyue Xi,Neil M. Ferguson,Christl A. Donnelly,Christl A. Donnelly +52 more
TL;DR: In this paper, the authors investigated the relationship between transmission and mobility for 52 countries around the world and found that mobility explained a substantial proportion of the variation in transmissibility (median adjusted R-squared: 48%, interquartile range - IQR - across countries [27-77%]).
Journal ArticleDOI
Producing polished prokaryotic pangenomes with the Panaroo pipeline
Gerry Tonkin-Hill,Gerry Tonkin-Hill,Neil MacAlasdair,Neil MacAlasdair,Christopher Ruis,Christopher Ruis,Aaron Weimann,Gal Horesh,John A. Lees,Rebecca A. Gladstone,Stephanie W. Lo,Christopher A. Beaudoin,R. Andres Floto,R. Andres Floto,Simon D. W. Frost,Simon D. W. Frost,Jukka Corander,Jukka Corander,Jukka Corander,Stephen D. Bentley,Julian Parkhill +20 more
TL;DR: Panaroo is introduced, a graph-based pangenome clustering tool that is able to account for many of the sources of error introduced during the annotation of prokaryotic genome assemblies.
Journal ArticleDOI
Fast and flexible bacterial genomic epidemiology with PopPUNK.
John A. Lees,Simon R. Harris,Gerry Tonkin-Hill,Rebecca A. Gladstone,Stephanie W. Lo,Jeffrey N. Weiser,Jukka Corander,Jukka Corander,Jukka Corander,Stephen D. Bentley,Stephen D. Bentley,Stephen D. Bentley,Nicholas J. Croucher +12 more
TL;DR: PopPUNK has been designed as a flexible platform that addresses important issues with currently used whole-genome clustering and typing methods, and has potential uses across bacterial genetics and public health research.
Posted ContentDOI
Producing Polished Prokaryotic Pangenomes with the Panaroo Pipeline
Gerry Tonkin-Hill,Gerry Tonkin-Hill,Neil MacAlasdair,Neil MacAlasdair,Christopher Ruis,Christopher Ruis,Aaron Weimann,Gal Horesh,John A. Lees,Rebecca A. Gladstone,Stephanie W. Lo,Christopher A. Beaudoin,R. Andres Floto,R. Andres Floto,Simon D. W. Frost,Simon D. W. Frost,Jukka Corander,Jukka Corander,Jukka Corander,Stephen D. Bentley,Julian Parkhill +20 more
TL;DR: Panaroo is introduced, a graph based pangenome clustering tool that is able to account for many of the sources of error introduced during the annotation of prokaryotic genome assemblies and is shown to have utility by performing a pan-genome wide association study in Neisseria gonorrhoeae and by analysing gene gain and loss rates across 51 of the major global pneumococcal sequence clusters.