S
Stephen D. Bentley
Researcher at Wellcome Trust Sanger Institute
Publications - 344
Citations - 37276
Stephen D. Bentley is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Population & Genome. The author has an hindex of 86, co-authored 313 publications receiving 32504 citations. Previous affiliations of Stephen D. Bentley include Wellcome Trust & University of Liverpool.
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Journal ArticleDOI
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
Stephen D. Bentley,Keith F. Chater,Ana Cerdeño-Tárraga,Gregory L. Challis,Gregory L. Challis,Nicholas R. Thomson,Keith D. James,David Harris,Michael A. Quail,H. M. Kieser,D. Harper,Alex Bateman,Steve D.M. Brown,Govind Chandra,Carton W. Chen,Mark O. Collins,Ann Cronin,Andrew G. Fraser,Arlette Goble,J. Hidalgo,T. Hornsby,S. Howarth,Chih-Hung Huang,Tobias Kieser,L. Larke,Lee Murphy,Karen Oliver,Susan O'Neil,Ester Rabbinowitsch,Marie-Adèle Rajandream,Kim Rutherford,Simon Rutter,Kathy Seeger,David L. Saunders,Sarah Sharp,R. Squares,S. Squares,K. Taylor,T. Warren,Andreas Wietzorrek,John Woodward,Bart Barrell,Julian Parkhill,David A. Hopwood +43 more
TL;DR: The 8,667,507 base pair linear chromosome of Streptomyces coelicolor is reported, containing the largest number of genes so far discovered in a bacterium.
Journal ArticleDOI
Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using Gubbins.
Nicholas J. Croucher,Andrew J. Page,Thomas R. Connor,Aidan Delaney,Jacqueline A. Keane,Stephen D. Bentley,Julian Parkhill,Simon R. Harris +7 more
TL;DR: Gubbins is an iterative algorithm that uses spatial scanning statistics to identify loci containing elevated densities of base substitutions suggestive of horizontal sequence transfer while concurrently constructing a maximum likelihood phylogeny based on the putative point mutations outside these regions of high sequence diversity.
Journal ArticleDOI
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
Julian Parkhill,Gordon Dougan,Keith D. James,Nicholas R. Thomson,Derek Pickard,John Wain,Carol Churcher,Karen Mungall,Stephen D. Bentley,Matthew T. G. Holden,Mohammed Sebaihia,Stephen Baker,D. Basham,Karen Brooks,Tracey Chillingworth,Phillippa L. Connerton,A. Cronin,P. Davis,Robert L. Davies,L. Dowd,Nicholas J. White,Jeremy Farrar,Theresa Feltwell,N. Hamlin,Ashraful Haque,Tran Tinh Hien,S. Holroyd,Kay Jagels,Anders Krogh,Torben Larsen,S. Leather,Sharon Moule,Peadar O'Gaora,Christopher M. Parry,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +40 more
TL;DR: The genome sequence is sequenced of a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands.
Journal ArticleDOI
Genome sequence of Yersinia pestis , the causative agent of plague
Julian Parkhill,Brendan W. Wren,Nicholas R. Thomson,Richard W. Titball,Matthew T. G. Holden,Michael B. Prentice,Mohammed Sebaihia,Keith D. James,Carol Churcher,Karen Mungall,Stephen Baker,D. Basham,Stephen D. Bentley,Karen Brooks,Ana Cerdeño-Tárraga,Tracey Chillingworth,A. Cronin,Robert L. Davies,P. Davis,Gordon Dougan,Theresa Feltwell,N. Hamlin,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,S. Leather,Sharon Moule,P. C. F. Oyston,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +34 more
TL;DR: The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.
Journal ArticleDOI
Evolution of MRSA During Hospital Transmission and Intercontinental Spread
Simon R. Harris,Edward J. Feil,Matthew T. G. Holden,Michael A. Quail,Emma K. Nickerson,Emma K. Nickerson,Narisara Chantratita,Susana Gardete,Susana Gardete,Ana Tavares,Nicholas P. J. Day,Nicholas P. J. Day,Jodi A. Lindsay,Jonathan D. Edgeworth,Jonathan D. Edgeworth,Hermínia de Lencastre,Hermínia de Lencastre,Julian Parkhill,Sharon J. Peacock,Sharon J. Peacock,Stephen D. Bentley +20 more
TL;DR: A high-throughput genomics approach is used to show that isolates of methicillin-resistant Staphylococcus aureus are precisely differentiated into a global geographic structure and suggest that intercontinental transmission has occurred for nearly four decades.