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John Blaikley

Researcher at University of Manchester

Publications -  50
Citations -  2460

John Blaikley is an academic researcher from University of Manchester. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 35 publications receiving 1818 citations. Previous affiliations of John Blaikley include University College London & University Hospital of South Manchester NHS Foundation Trust.

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The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

TL;DR: It is demonstrated that the macrophage clockwork provides temporal gating of systemic responses to endotoxin, and REV-ERBα is identified as the key link between the clock and immune function, and may represent a unique therapeutic target in human inflammatory disease.
Journal ArticleDOI

Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing.

TL;DR: It is suggested that circadian regulation of the cytoskeleton influences wound-healing efficacy from the cellular to the organismal scale, as well as the observation that the time of injury significantly affects healing after burns in humans, with daytime wounds healing faster than nighttime wounds.