M
Marrit Putker
Researcher at Laboratory of Molecular Biology
Publications - 21
Citations - 1177
Marrit Putker is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Medicine & Circadian rhythm. The author has an hindex of 10, co-authored 15 publications receiving 849 citations. Previous affiliations of Marrit Putker include University of Cambridge & Utrecht University.
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Journal ArticleDOI
Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy
Kristan E. van der Vos,Pernilla Eliasson,Tassula Proikas-Cezanne,Stephin J. Vervoort,Stephin J. Vervoort,Ruben van Boxtel,Marrit Putker,Iris J. van Zutphen,Mario Mauthe,Sebastian Zellmer,Cornelieke Pals,Liesbeth P. Verhagen,Marian J. A. Groot Koerkamp,A. Koen Braat,A. Koen Braat,Tobias B. Dansen,Frank C. P. Holstege,Rolf Gebhardt,Boudewijn M.T. Burgering,Paul J. Coffer,Paul J. Coffer +20 more
TL;DR: A growth-factor-responsive network that can directly modulate autophagy through the regulation of glutamine metabolism is revealed, suggesting that the induction ofautophagy by FOXO3-mediated glutamine synthetase expression is important for cellular survival.
Journal ArticleDOI
Daily magnesium fluxes regulate cellular timekeeping and energy balance
Kevin A. Feeney,Louise L Hansen,Marrit Putker,Consuelo Olivares-Yañez,Jason Day,Lorna J. Eades,Luis F. Larrondo,Nathaniel P. Hoyle,John S. O’Neill,Gerben van Ooijen +9 more
TL;DR: In this article, the intracellular concentration of magnesium ions, [Mg(2+)]i, was found to act as a cell-autonomous timekeeping component to determine key clock properties both in a human cell line and in a unicellular alga.
Journal ArticleDOI
Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
Priya Crosby,Ryan Hamnett,Marrit Putker,Nathaniel P. Hoyle,Martin Reed,Carolyn J. Karam,Elizabeth S. Maywood,Alessandra Stangherlin,Johanna E. Chesham,Edward A. Hayter,Lyn Rosenbrier-Ribeiro,Peter Newham,Hans Clevers,David A. Bechtold,John S. O’Neill +14 more
TL;DR: It is proposed insulin and IGF-1 are primary signals of feeding time to cellular clocks throughout the body and require coincident mechanistic target of rapamycin (mTOR) activation, increased phosphoinositide signaling, and microRNA downregulation.
Journal ArticleDOI
Redox-dependent control of FOXO/DAF-16 by transportin-1
Marrit Putker,Tobias Madl,Harmjan R. Vos,Hesther de Ruiter,Marieke Visscher,Maaike C. W. van den Berg,Mohammed Kaplan,Hendrik C. Korswagen,Rolf Boelens,Michiel Vermeulen,Boudewijn M.T. Burgering,Tobias B. Dansen +11 more
TL;DR: It is shown that disulfide formation with transportin-1 is required for nuclear localization and the activation of FOXO4/DAF-16 induced by ROS, but not by the loss of insulin signaling, and this molecular mechanism for nuclear shuttling is conserved in C. elegans.
Journal ArticleDOI
Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing.
Nathaniel P. Hoyle,Estere Seinkmane,Marrit Putker,Kevin A. Feeney,Toke P. Krogager,Johanna E. Chesham,Liam K. Bray,Justyn M. Thomas,Ken Dunn,John Blaikley,John S. O’Neill +10 more
TL;DR: It is suggested that circadian regulation of the cytoskeleton influences wound-healing efficacy from the cellular to the organismal scale, as well as the observation that the time of injury significantly affects healing after burns in humans, with daytime wounds healing faster than nighttime wounds.