John Concato

TL;DR: Among older persons, the LMS approach (vs the GOLD approach) classifies respiratory impairment less frequently in those who are asymptomatic and is more strongly associated with mobility disability.

TL;DR: Although the majority of patients switched preferences to cyclophosphamide for better renal survival, a substantial minority was unwilling to accept the toxicity associated with cycloph phosphamide, even if it was much better than azathioprine at preventing renal failure.

TL;DR: The association of LMS-defined respiratory impairment (airflow limitation and restrictive pattern) with all-cause mortality and respiratory symptoms (chronic bronchitis, dyspnea, or wheezing) in older persons supports the use of L MS-derived spirometric z scores as a basis for evaluating respiratory impairment in older people.

TL;DR: Conflicting results from RCTs can represent a spectrum of "real" outcomes for specific treatments, and such trials are best evaluated by considering concurrently both the validity of study design as well as the generalizability of patients and interventions involved.

TL;DR: The TNM status of recurrent tumors predicts mortality, but constrictor muscle invasion and weight loss also have major prognostic importance, and the consolidation of these variables into a composite staging system successfully stratifies patients with widely divergent mortality rates.