John E. Linz

TL;DR: Aflatoxins, a group of polyketide-derived furanocoumarins, are the most toxic and carcinogenic compounds among the known mycotoxins and there are only four major aflatoxINS, B1, B2, G1, and G2.

TL;DR: The physical distances (in kilobase pairs) and the directions of transcription of these genes have been determined for both aflatoxigenic species and the order is related to the order in enzymatic steps required for aflatoxin biosynthesis.

TL;DR: An Aspergillus parasiticus gene, designated apa-2, was identified as a regulatory gene associated with aflatoxin biosynthesis and was found to complement an A. flavus afl-2 mutant strain for a flatoxin production, suggesting that apA-2 is functionally homologous to aFL-2.

TL;DR: A unique 2-branch model is proposed to illustrate the proposed role for VeA in regulation of aflatoxisome development and aflatoxin gene expression, which is at least in part mediated by Velvet, a global regulator of Aspergillus secondary metabolism.

TL;DR: DNA isolated from the wild-type aflatoxin-producing fungus Aspergillus parasiticus NRRL 5862 was used to construct a cosmid genomic DNA library employing the homologous gene (pyrG) encoding orotidine monophosphate decarboxylase for selection of fungal transformants, revealing striking similarity with Streptomyces ketoreductases involved in polyketide biosynthesis.