J
John Hart
Researcher at Duke University
Publications - 4
Citations - 1455
John Hart is an academic researcher from Duke University. The author has contributed to research in topics: Major histocompatibility complex & Linkage disequilibrium. The author has an hindex of 4, co-authored 4 publications receiving 1383 citations.
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Journal ArticleDOI
A high resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
Paul I.W. de Bakker,Gil McVean,Pardis C. Sabeti,Marcos Mateo Miretti,Todd Green,Jonathan Marchini,Xiayi Ke,Alienke J. Monsuur,Pamela Whittaker,Marcos Delgado,Jonathan Morrison,Angela Richardson,Emily C. Walsh,Xiaojiang Gao,Luana Galver,John Hart,David A. Hafler,David A. Hafler,Margaret A. Pericak-Vance,John A. Todd,Mark J. Daly,Mark J. Daly,John Trowsdale,Cisca Wijmenga,Timothy J. Vyse,Stephan Beck,Sarah S. Murray,Mary Carrington,Simon G. Gregory,Panos Deloukas,John D. Rioux,John D. Rioux,John D. Rioux +32 more
TL;DR: The analysis provides informative tag SNPs that capture much of the common variation in the MHC region and that could be used in disease association studies, and it provides new insight into the evolutionary dynamics and ancestral origins of the HLA loci and their haplotypes.
Journal ArticleDOI
Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis
Simon G. Gregory,Silke Schmidt,Puneet Seth,Jorge R. Oksenberg,John Hart,Angela Prokop,Stacy J. Caillier,Maria Ban,An Goris,Lisa F. Barcellos,Robin R. Lincoln,Jacob L. McCauley,Stephen Sawcer,D. A. S. Compston,Bénédicte Dubois,Stephen L. Hauser,Mariano A. Garcia-Blanco,Margaret A. Pericak-Vance,Jonathan L. Haines +18 more
TL;DR: Allelic association of a polymorphism in the gene encoding the interleukin 7 receptor α chain ( IL7R) is described as a significant risk factor for multiple sclerosis in four independent family-based or case-control data sets.
Journal ArticleDOI
Staged Approach to Invasive Vesical Malignancy
Journal ArticleDOI
Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis
Silke Schmidt,Margaret A. Pericak-Vance,Stephen Sawcer,Lisa F. Barcellos,Lisa F. Barcellos,John Hart,Joshua J. Sims,A. M. Prokop,J. M. Van Der Walt,Carolyn Deloa,Robin R. Lincoln,Jorge R. Oksenberg,Alastair Compston,Stephen L. Hauser,J. L. Haines,Simon G. Gregory +15 more
TL;DR: The analysis of a very large data set suggests that genetic polymorphisms in PVRL2 may influence MS severity and supports the possibility that viral factors may contribute to the clinical course of MS, consistent with previous reports.