J
John D. Rioux
Researcher at Université de Montréal
Publications - 266
Citations - 56872
John D. Rioux is an academic researcher from Université de Montréal. The author has contributed to research in topics: Genome-wide association study & Inflammatory bowel disease. The author has an hindex of 88, co-authored 250 publications receiving 52749 citations. Previous affiliations of John D. Rioux include Broad Institute & Brigham and Women's Hospital.
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Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Richard H. Duerr,Kent D. Taylor,Steven R. Brant,Steven R. Brant,John D. Rioux,John D. Rioux,Mark S. Silverberg,Mark J. Daly,Mark J. Daly,A. Hillary Steinhart,Clara Abraham,Miguel Regueiro,Anne M. Griffiths,Themistocles Dassopoulos,Alain Bitton,Huiying Yang,Stephan R. Targan,Lisa W. Datta,Emily O. Kistner,L. Philip Schumm,Annette Lee,Peter K. Gregersen,M. Michael Barmada,Jerome I. Rotter,Dan L. Nicolae,Judy H. Cho +25 more
TL;DR: A highly significant association is found between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23, which prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.
Genetic studies of body mass index yield new insights for obesity biology
Adam E. Locke,Bratati Kahali,Sonja I. Berndt,Anne E. Justice,Tune H. Pers,Felix R. Day,Corey Powell,Sailaja Vedantam,Martin L. Buchkovich,Jian Yang,Damien C. Croteau-Chonka,Tõnu Esko,Tove Fall,Teresa Ferreira,Stefan Gustafsson,Zoltán Kutalik,Jian'an Luan,Reedik Mägi,Joshua C. Randall,Thomas W. Winkler,Andrew R. Wood,Tsegaselassie Workalemahu,Jessica D. Faul,Jennifer A. Smith,Jing Hua Zhao,Wei Zhao,Jin Chen,Rudolf S N Fehrmann,Åsa K. Hedman,Juha Karjalainen,Ellen M. Schmidt,Devin Absher,Najaf Amin,Denise Anderson,Marian Beekman,Jennifer L. Bolton,Jennifer L. Bragg-Gresham,Steven Buyske,Ayse Demirkan,Guohong Deng,Georg Ehret,Bjarke Feenstra,Mary F. Feitosa,Krista Fischer,Anuj Goel,Jian Gong,Anne U. Jackson,Stavroula Kanoni,Marcus E. Kleber,Kati Kristiansson,Unhee Lim,Vaneet Lotay,Massimo Mangino,Irene Mateo Leach,Carolina Medina-Gomez,Sarah E. Medland,Mike A. Nalls,Cameron D. Palmer,Dorota Pasko,Sonali Pechlivanis,Marjolein Peters,Inga Prokopenko,Dmitry Shungin,Alena Stančáková,Rona J. Strawbridge,Yun Ju Sung,Toshiko Tanaka,Alexander Teumer,Stella Trompet,Sander W. van der Laan,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Zhaoming Wang,Loic Yengo,Weihua Zhang,Aaron Isaacs,Eva Albrecht,Johan Ärnlöv,Gillian M. Arscott,Antony P. Attwood,Stefania Bandinelli,Amy Barrett,Isabelita Bas,Claire Bellis,Amanda J. Bennett,Christian Berne,Roza Blagieva,Matthias Blüher,Stefan Böhringer,Lori L. Bonnycastle,Yvonne Böttcher,Heather A. Boyd,Marcel Bruinenberg,Ida Henriette Caspersen,Yii-Der Ida Chen,Robert Clarke,E. Warwick Daw,Anton J. M. de Craen,Graciela E. Delgado,Maria Dimitriou,Alex S. F. Doney,Niina Eklund,Karol Estrada,Elodie Eury,Lasse Folkersen,Ross M. Fraser,Melissa E. Garcia,Frank Geller,Vilmantas Giedraitis,Bruna Gigante,Alan S. Go,Alain Golay,Alison H. Goodall,Scott D. Gordon,Mathias Gorski,Hans-Jörgen Grabe,Harald Grallert,Tanja B. Grammer,Jürgen Gräßler,Henrik Grönberg,Christopher J. Groves,Gaëlle Gusto,Jeffrey Haessler,Per Hall,Toomas Haller,Göran Hallmans,Catharina A. Hartman,Maija Hassinen,Caroline Hayward,Nancy L. Heard-Costa,Quinta Helmer,Christian Hengstenberg,Oddgeir L. Holmen,Jouke-Jan Hottenga,Alan James,Janina M. Jeff,Åsa Johansson,Jennifer Jolley,Thorhildur Juliusdottir,Leena Kinnunen,Wolfgang Koenig,Markku Koskenvuo,Wolfgang Kratzer,Jaana Laitinen,Claudia Lamina,Karin Leander,Nanette R. Lee,Peter Lichtner,Lars Lind,Jaana Lindström,Ken Sin Lo,Stéphane Lobbens,Roberto Lorbeer,Yingchang Lu,François Mach,Patrik K. E. Magnusson,Anubha Mahajan,Wendy L. McArdle,Stela McLachlan,Cristina Menni,Sigrun Merger,Evelin Mihailov,Lili Milani,Alireza Moayyeri,Keri L. Monda,Mario A. Morken,Antonella Mulas,Gabriele Müller,Martina Müller-Nurasyid,Arthur W. Musk,Ramaiah Nagaraja,Markus M. Nöthen,Ilja M. Nolte,Stefan Pilz,Nigel W. Rayner,Frida Renström,Rainer Rettig,Janina S. Ried,Stephan Ripke,Neil R. Robertson,Lynda M. Rose,Serena Sanna,Hubert Scharnagl,Salome Scholtens,Fredrick R. Schumacher,William R. Scott,Thomas Seufferlein,Jianxin Shi,Albert V. Smith,Joanna Smolonska,Alice Stanton,Valgerdur Steinthorsdottir,Kathleen Stirrups,Heather M. Stringham,Johan Sundström,Morris A. Swertz,Amy J. Swift,Ann-Christine Syvänen,Sian-Tsung Tan,Bamidele O. Tayo,Barbara Thorand,Gudmar Thorleifsson,Jonathan Tyrer,Hae-Won Uh,Liesbeth Vandenput,Frank C. Verhulst,Sita H. Vermeulen,Niek Verweij,Judith M. Vonk,Lindsay L. Waite,Helen R. Warren,Dawn M. Waterworth,Michael N. Weedon,Lynne R. Wilkens,Christina Willenborg,Tom Wilsgaard,Mary K. Wojczynski,Andrew Wong,Alan F. Wright,Qunyuan Zhang,Eoin P. Brennan,Murim Choi,Zari Dastani,Alexander W. Drong,Per Eriksson,Anders Franco-Cereceda,Jesper R. Gådin,Ali G. Gharavi,Michael E. Goddard,Robert E. Handsaker,Jinyan Huang,Fredrik Karpe,Sekar Kathiresan,Sarah Keildson,Krzysztof Kiryluk,Michiaki Kubo,Jong-Young Lee,Liming Liang,Richard P. Lifton,Baoshan Ma,Steven A. McCarroll,Amy Jayne McKnight,Josine L. Min,Miriam F. Moffatt,Grant W. Montgomery,Joanne M. Murabito,George Nicholson,Dale R. Nyholt,Yukinori Okada,John R. B. Perry,Rajkumar Dorajoo,Eva Reinmaa,Rany M. Salem,Niina Sandholm,Robert A. Scott,Lisette Stolk,Atsushi Takahashi,Toshihiro Tanaka,Ferdinand M. van't Hooft,Anna A. E. Vinkhuyzen,Harm-Jan Westra,Wei Zheng,Krina T. Zondervan,Andrew C. Heath,Dominique Arveiler,Stephan J. L. Bakker,John Beilby,Richard N. Bergman,John Blangero,Pascal Bovet,Harry Campbell,Mark J. Caulfield,Giancarlo Cesana,Aravinda Chakravarti,Daniel I. Chasman,Peter S. Chines,Francis S. Collins,Dana C. Crawford,L. Adrienne Cupples,Daniele Cusi,John Danesh,Ulf de Faire,Hester M. den Ruijter,Anna F. Dominiczak,Raimund Erbel,Jeanette Erdmann,Johan G. Eriksson,Martin Farrall,Stephan B. Felix,Ele Ferrannini,Jean Ferrières,Ian Ford,Nita G. Forouhi,Terrence Forrester,Oscar H. Franco,Ron T. Gansevoort,Pablo V. Gejman,Christian Gieger,Omri Gottesman,Vilmundur Gudnason,Ulf Gyllensten,Alistair S. Hall,Tamara B. Harris,Andrew T. Hattersley,Andrew A. Hicks,Lucia A. Hindorff,Aroon D. Hingorani,Albert Hofman,Georg Homuth,G. Kees Hovingh,Steve E. Humphries,Steven C. Hunt,Elina Hyppönen,Thomas Illig,Kevin B. Jacobs,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Berit Johansen,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Jaakko Kaprio,John J.P. Kastelein,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Paul Knekt,Jaspal S. Kooner,Charles Kooperberg,Peter Kovacs,Aldi T. Kraja,Meena Kumari,Johanna Kuusisto,Timo A. Lakka,Claudia Langenberg,Loic Le Marchand,Terho Lehtimäki,Valeriya Lyssenko,Satu Männistö,André Marette,Tara C. Matise,Colin A. McKenzie,Barbara McKnight,Frans L. Moll,Andrew D. Morris,Andrew P. Morris,Jeffrey C. Murray,Mari Nelis,Claes Ohlsson,Albertine J. Oldehinkel,Ken K. Ong,Pamela A. F. Madden,Gerard Pasterkamp,John F. Peden,Annette Peters,Dirkje S. Postma,Peter P. Pramstaller,Jackie F. Price,Lu Qi,Olli T. Raitakari,Tuomo Rankinen,Dabeeru C. Rao,Treva Rice,Paul M. Ridker,John D. Rioux,Marylyn D. Ritchie,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Jouko Saramies,Mark A. Sarzynski,Heribert Schunkert,Peter Schwarz,Peter S. Sever,Alan R. Shuldiner,Juha Sinisalo,Ronald P. Stolk,Konstantin Strauch,Anke Tönjes,David-Alexandre Trégouët,Angelo Tremblay,Elena Tremoli,Jarmo Virtamo,Marie-Claude Vohl,Uwe Völker,Gérard Waeber,Gonneke Willemsen,Jacqueline C. M. Witteman,M. Carola Zillikens,Linda S. Adair,Philippe Amouyel,Folkert W. Asselbergs,Themistocles L. Assimes,Murielle Bochud,Bernhard O. Boehm,Eric Boerwinkle,Stefan R. Bornstein,Erwin P. Bottinger,Claude Bouchard,Stéphane Cauchi,John C. Chambers,Stephen J. Chanock,Richard S. Cooper,Paul I.W. de Bakker,George Dedoussis,Luigi Ferrucci,Paul W. Franks,Philippe Froguel,Leif Groop,Christopher A. Haiman,Anders Hamsten,Jennie Hui,David J. Hunter,Kristian Hveem,Robert C. Kaplan,Mika Kivimäki,Diana Kuh,Markku Laakso,Yongmei Liu,Nicholas G. Martin,Winfried März,Mads Melbye,Andres Metspalu,Susanne Moebus,Patricia B. Munroe,Inger Njølstad,Ben A. Oostra,Colin N. A. Palmer,Nancy L. Pedersen,Markus Perola,Louis Pérusse,Ulrike Peters,Chris Power,Thomas Quertermous,Rainer Rauramaa,Fernando Rivadeneira,Timo Saaristo,Danish Saleheen,Naveed Sattar,Eric E. Schadt,David Schlessinger,P. Eline Slagboom,Harold Snieder,Tim D. Spector,Unnur Thorsteinsdottir,Michael Stumvoll,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Pim van der Harst,Mark Walker,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,David R. Weir,H-Erich Wichmann,James F. Wilson,Pieter Zanen,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Iris M. Heid,Jeffrey R. O'Connell,David P. Strachan,Kari Stefansson,Cornelia M. van Duijn,Gonçalo R. Abecasis,Lude Franke,Timothy M. Frayling,Mark I. McCarthy,Peter M. Visscher,André Scherag,Cristen J. Willer,Michael Boehnke,Karen L. Mohlke,Cecilia M. Lindgren,Jacques S. Beckmann,Inês Barroso,Kari E. North,Erik Ingelsson,Joel N. Hirschhorn,Ruth J. F. Loos,Elizabeth K. Speliotes +481 more
TL;DR: This paper conducted a genome-wide association study and meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals.
Journal ArticleDOI
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Jeffrey C. Barrett,Sarah Hansoul,Dan L. Nicolae,Judy H. Cho,Richard H. Duerr,John D. Rioux,John D. Rioux,Steven R. Brant,Mark S. Silverberg,Kent D. Taylor,M. Michael Barmada,Alain Bitton,Themistocles Dassopoulos,Lisa W. Datta,Todd Green,Anne M. Griffiths,Emily O. Kistner,Michael T. Murtha,Miguel Regueiro,Jerome I. Rotter,L. Philip Schumm,A. Hillary Steinhart,Stephan R. Targan,Ramnik J. Xavier,Cécile Libioulle,Cynthia Sandor,Mark Lathrop,Jacques Belaiche,Olivier Dewit,Ivo Gut,Simon Heath,Debby Laukens,Myriam Mni,Paul Rutgeerts,André Van Gossum,Diana Zelenika,Denis Franchimont,Jean-Pierre Hugot,Martine De Vos,Severine Vermeire,Edouard Louis,Lon R. Cardon,Carl A. Anderson,Hazel E. Drummond,Elaine R. Nimmo,Tariq Ahmad,Natalie J. Prescott,Clive M. Onnie,Sheila A. Fisher,Jonathan Marchini,Jilur Ghori,Suzannah Bumpstead,Rhian Gwilliam,Mark Tremelling,Panos Deloukas,John C. Mansfield,Derek P. Jewell,Jack Satsangi,Christopher G. Mathew,Miles Parkes,Michel Georges,Mark J. Daly,Mark J. Daly +62 more
TL;DR: The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1, which offer promise for informed therapeutic development.
Journal ArticleDOI
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Stephen Sawcer,Garrett Hellenthal,Matti Pirinen,Chris C. A. Spencer,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Loukas Moutsianas,Alexander T. Dilthey,Zhan Su,Colin Freeman,Sarah E. Hunt,Sarah Edkins,Emma Gray,David R. Booth,Simon C. Potter,An Goris,Gavin Band,Annette Bang Oturai,A. Strange,Janna Saarela,Céline Bellenguez,Bertrand Fontaine,Matthew W. Gillman,Bernhard Hemmer,Rhian Gwilliam,Frauke Zipp,Alagurevathi Jayakumar,Roland Martin,Stephen Leslie,Stanley Hawkins,Eleni Giannoulatou,Sandra D'Alfonso,Hannah Blackburn,Filippo Martinelli Boneschi,Jennifer Liddle,Hanne F. Harbo,Hanne F. Harbo,M. Perez,Anne Spurkland,Matthew Waller,Marcin P. Mycko,Michelle Ricketts,Manuel Comabella,Naomi Hammond,Ingrid Kockum,O. T. McCann,Maria Ban,Pamela Whittaker,Anu Kemppinen,Paul A. Weston,Clive Hawkins,Sara Widaa,John Zajicek,John Zajicek,Serge Dronov,Neil Robertson,Suzannah Bumpstead,Lisa F. Barcellos,Lisa F. Barcellos,Rathi Ravindrarajah,Roby Abraham,Lars Alfredsson,Kristin G. Ardlie,Cristin Aubin,Amie Baker,K Baker,Sergio E. Baranzini,Laura Bergamaschi,Roberto Bergamaschi,Allan L. Bernstein,Achim Berthele,Mike Boggild,Jonathan P. Bradfield,David Brassat,Simon Broadley,Dorothea Buck,Helmut Butzkueven,Ruggero Capra,William M. Carroll,Paola Cavalla,Elisabeth Gulowsen Celius,Sabine Cepok,Rosetta M. Chiavacci,Françoise Clerget-Darpoux,Katleen Clysters,Giancarlo Comi,Mark D. Cossburn,Isabelle Cournu-Rebeix,M. B. Cox,Wendy Cozen,Bruce A.C. Cree,Anne H. Cross,Daniele Cusi,Mark J. Daly,Mark J. Daly,Emma J. Davis,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Marc Debouverie,Marie B. D'hooghe,K Dixon,Rita Dobosi,Bénédicte Dubois,David Ellinghaus,Irina Elovaara,Federica Esposito,Claire Fontenille,Simon J. Foote,Andre Franke,Daniela Galimberti,Angelo Ghezzi,Joseph T. Glessner,Refujia Gomez,Olivier Gout,Colin A. Graham,Struan F.A. Grant,Struan F.A. Grant,Franca Rosa Guerini,Hakon Hakonarson,Hakon Hakonarson,Per Hall,Anders Hamsten,Hans-Peter Hartung,Robert Heard,Simon Heath,Jeremy Hobart,Jeremy Hobart,Muna Hoshi,Carmen Infante-Duarte,Gillian Ingram,Wendy Ingram,Wendy Ingram,Talat Islam,Maja Jagodic,Michael Kabesch,Allan G. Kermode,Trevor J. Kilpatrick,Cecilia Kim,Norman Klopp,Keijo Koivisto,Malin Larsson,Mark Lathrop,Jeannette Lechner-Scott,Maurizio Leone,Virpi M. Leppä,Ulrika Liljedahl,Izaura Lima Bomfim,Robin R. Lincoln,Jenny Link,Jianjun Liu,Åslaug R. Lorentzen,Åslaug R. Lorentzen,Sara Lupoli,Fabio Macciardi,Fabio Macciardi,Thomas M. Mack,Mark Marriott,Vittorio Martinelli,Deborah F. Mason,Jacob L. McCauley,Frank D. Mentch,Inger-Lise Mero,Tania Mihalova,Xavier Montalban,John Mottershead,Kjell-Morten Myhr,Paola Naldi,William E R Ollier,Alison Page,Aarno Palotie,Jean Pelletier,Laura Piccio,Trevor Pickersgill,Fredrik Piehl,Susan Pobywajlo,Hong L. Quach,Patricia P. Ramsay,Mauri Reunanen,Richard Reynolds,John D. Rioux,John D. Rioux,Mariaemma Rodegher,Sabine Roesner,Justin P. Rubio,Ina-Maria Rueckert,Marco Salvetti,Erika Salvi,Adam Santaniello,Catherine Schaefer,Stefan Schreiber,Christian Schulze,Rodney J. Scott,Finn Sellebjerg,Krzysztof Selmaj,David Sexton,Ling Shen,Brigid Simms-Acuna,Sheila Skidmore,Patrick M. A. Sleiman,C. Smestad,Per Soelberg Sørensen,Helle Bach Søndergaard,Jim Stankovich,Richard C. Strange,Anna-Maija Sulonen,Emilie Sundqvist,Ann-Christine Syvaenen,Francesca Taddeo,Bruce V. Taylor,Jenefer M. Blackwell,Jenefer M. Blackwell,Jenefer M. Blackwell,Pentti J. Tienari,Elvira Bramon,Ayman Tourbah,Matthew A. Brown,Ewa Tronczynska,Juan P. Casas,Niall Tubridy,Aiden Corvin,Jane Vickery,Jane Vickery,Janusz Jankowski,Pablo Villoslada,Hugh S. Markus,Kai Wang,Christopher G. Mathew,James Wason,Colin N. A. Palmer,H-Erich Wichmann,H-Erich Wichmann,Robert Plomin,Ernest Willoughby,Anna Rautanen,Juliane Winkelmann,Michael Wittig,Richard C. Trembath,J. Yaouanq,Ananth C. Viswanathan,Ananth C. Viswanathan,Haitao Zhang,Nicholas W. Wood,Rebecca L. Zuvich,Panos Deloukas,Cordelia Langford,Audrey Duncanson,Jorge R. Oksenberg,Margaret A. Pericak-Vance,Jonathan L. Haines,Tomas Olsson,Jan Hillert,Adrian J. Ivinson,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Leena Peltonen,Graeme J. Stewart,David A. Hafler,David A. Hafler,Stephen L. Hauser,Gil McVean,Peter Donnelly,Peter Donnelly,Alastair Compston +265 more
TL;DR: In this article, a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, they have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci.