J
John J. Suschak
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 26
Citations - 624
John J. Suschak is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: DNA vaccination & Immunogenicity. The author has an hindex of 10, co-authored 19 publications receiving 461 citations. Previous affiliations of John J. Suschak include United States Department of the Army & University of Massachusetts Medical School.
Papers
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Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity
TL;DR: Advances in DNA vaccine vector design, the inclusion of genetically engineered cytokine adjuvants, and novel non-mechanical delivery methods show promise for increasing the immunogenicity of DNA vaccines.
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A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
TL;DR: The results showed that DNA vaccine–induced, Irf7-dependent signaling, as part of the Sting pathway, was critical for generation of both innate cytokine signaling and Ag-specific B and T cell responses, and, more surprisingly, immune responses elicited by DNA vaccines were not cGas-dependent in vivo.
Book
A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models
Aura R. Garrison,Charles J. Shoemaker,Joseph W. Golden,Collin J. Fitzpatrick,John J. Suschak,Michelle J. Richards,Catherine V. Badger,Carolyn M. Six,Jacqueline D. Martin,Drew Hannaman,Marko Zivcec,Eric Bergeron,Jeffrey W. Koehler,Connie S. Schmaljohn +13 more
TL;DR: Supportive data is offered indicating that a DNA vaccine expressing the M-segment glycoprotein precursor gene of CCHFV elicits protective immunity against CCHfV and that type I interferon receptor knockout mice had a more balanced Th1/Th2 response to vaccination.
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Identification of Aim2 as a Sensor for DNA Vaccines
TL;DR: Results indicate a previously unreported link between DNA vaccine–induced pyroptotic cell death and vaccine immunogenicity that is instrumental in shaping the Ag-specific immune response to DNA vaccines.
Journal ArticleDOI
Molecular methods for evaluation of virological status of nonhuman primates challenged with simian immunodeficiency or simian-human immunodeficiency viruses.
Eun Mi Lee,Hye-Kyung Chung,Jessica Livesay,John J. Suschak,Lindsay Finke,Lauren Hudacik,Lindsey Galmin,Britany Bowen,Phillip D. Markham,Anthony D. Cristillo,Ranajit Pal +10 more
TL;DR: The results suggest that simultaneous application of real-time NASBA and PCR assays provides quantitative evaluation of challenge outcome in macaques.