抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Surface plasmons are waves that propagate along the surface of a conductor. By altering the structure of a metal's surface, the properties of surface plasmons--in particular their interaction with light--can be tailored, which offers the potential for developing new types of photonic device. This could lead to miniaturized photonic circuits with length scales that are much smaller than those currently achieved. Surface plasmons are being explored for their potential in subwavelength optics, data storage, light generation, microscopy and bio-photonics.

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Surface plasmon subwavelength optics

12.2.2. Four-Wave Mixing (FWM) 4849 12.2.3. Dye Aggregation 4850 12.2.4. Optoelectronic Nanodevices 4850 12.3. Sensor 4851 12.3.1. Chemical Sensor 4851 12.3.2. Biological Sensor 4851 12.4. Catalysis 4852 13. Conclusion and Perspectives 4852 14. Abbreviations 4853 15. Acknowledgements 4854 16. References 4854 * Corresponding author E-mail: tpal@chem.iitkgp.ernet.in. † Raidighi College. § Indian Institute of Technology. 4797 Chem. Rev. 2007, 107, 4797−4862

Interparticle Coupling Effect on the Surface Plasmon Resonance of Gold Nanoparticles: From Theory to Applications

Some of the most sensitive methods of measuring magnetic fields use interactions of resonant light with atomic vapour. Recent developments in this vibrant field have led to improvements in sensitivity and other characteristics of atomic magnetometers, benefiting their traditional applications for measurements of geomagnetic anomalies and magnetic fields in space, and opening many new areas previously accessible only to magnetometers based on superconducting quantum interference devices. We review basic principles of modern optical magnetometers, discuss fundamental limitations on their performance, and describe recently explored applications for dynamical measurements of biomagnetic fields, detecting signals in NMR and MRI, inertial rotation sensing, magnetic microscopy with cold atoms, and tests of fundamental symmetries of nature.

/pdf/optical-magnetometry-escholarship-2a9vyl49vm.pdf

Optical magnetometry - eScholarship

http://myweb.rz.uni-augsburg.de/~eckern/WEH-287/ABSTRACTS/ruitenbeek.pdf

Quantum properties of atomic-sized conductors

Fabrication techniques usually applied to microelectromechanical systems (MEMS) are used to reduce the size and operating power of the core physics assembly of an atomic clock. With a volume of 9.5mm3, a fractional frequency instability of 2.5×10−10 at 1s of integration, and dissipating less than 75mW of power, the device has the potential to bring atomically precise timing to hand-held, battery-operated devices. In addition, the design and fabrication process allows for wafer-level assembly of the structures, enabling low-cost mass-production of thousands of identical units with the same process sequence, and easy integration with other electronics.

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A microfabricated atomic clock

Using the techniques of microelectromechanical systems, we have constructed a small low-power magnetic sensor based on alkali atoms. We use a coherent population trapping resonance to probe the interaction of the atoms’ magnetic moment with a magnetic field, and we detect changes in the magnetic flux density with a sensitivity of 50pTHz−1∕2 at 10Hz. The magnetic sensor has a size of 12mm3 and dissipates 195mW of power. Further improvements in size, power dissipation, and magnetic field sensitivity are immediately foreseeable, and such a device could provide a hand-held battery-operated magnetometer with an atom shot-noise limited sensitivity of 0.05pTHz−1∕2.

/pdf/chip-scale-atomic-magnetometer-1d0rfimhpd.pdf

Chip-scale atomic magnetometer

We describe the fabrication of chip-sized alkali atom vapor cells using silicon micromachining and anodic bonding technology. Such cells may find use in highly miniaturized atomic frequency references or magnetometers. The cells consist of cavities etched in silicon, with internal volumes as small as 1 mm3. Two techniques for introducing cesium and a buffer gas into the cells are described: one based on chemical reaction between cesium chloride and barium azide, and the other based on direct injection of elemental cesium within a controlled anaerobic environment. Cesium optical absorption and coherent population trapping resonances were measured in the cells.

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Microfabricated alkali atom vapor cells

An Nb‐Sn filament mounted on a flexible glass beam can be broken to form an electron tunneling junction between the fracture elements. Breaking the filament in liquid helium prevents oxidation of the freshly exposed fracture surfaces. A sharp superconducting energy gap in the I‐V characteristics measured at 4 K indicates the formation of a high‐quality tunneling barrier between the fracture elements. The resistance of the junction can be continuously adjusted by varying the surface bending strain of the beam. An estimated 0.1 nm change in the barrier thickness produces about an order of magnitude change in the resistance over the range from 105 to 108 Ω. The exponential character of this dependence shows that the tunnel junction is freely adjustable without intimate contact of the junction elements. ‘‘Break’’ junctions made in this way offer a new class of tunneling experiments on freshly exposed surfaces of a fractured sample without the oxide barrier previously required for junction stability. Such expe...

Electron tunneling experiments using Nb‐Sn ‘‘break’’ junctions

Chip-scale atomic devices combine elements of precision atomic spectroscopy, silicon micromachining, and advanced diode laser technology to create compact, low-power, and manufacturable instruments with high precision and stability. Microfabricated alkali vapor cells are at the heart of most of these technologies, and the fabrication of these cells is discussed in detail. We review the design, fabrication, and performance of chip-scale atomic clocks, magnetometers, and gyroscopes and discuss many applications in which these novel instruments are being used. Finally, we present prospects for future generations of miniaturized devices, such as photonically integrated systems and manufacturable devices, which may enable embedded absolute measurement of a broad range of physical quantities.

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John M. Moreland

Papers

A microfabricated atomic clock

Chip-scale atomic magnetometer

Microfabricated alkali atom vapor cells

Electron tunneling experiments using Nb‐Sn ‘‘break’’ junctions

Chip scale atomic devices