John Patrickson

TL;DR: The hypothesis that certain Fc receptor functions promote the rapid induction of elevated T helper type 1 (Th1) response, which effectively clears chlamydiae, provides a mechanistic basis for requiring both T cell and humoral immune responses in protective immunity and vaccine evaluation.

TL;DR: Results indicate that CXCL10 induces apoptosis in HBVECs and neuroglia cells in a dose-dependent manner suggesting that increased levels of CX CL10 in CM patients may play a role in vasculopathy, neuropathogenesis, and brain injury during CM pathogenesis.

TL;DR: The data indicate that Heme/HO-1, CXCL10/CXCR3 and STAT3 molecules as well as related signaling pathways play very important roles in the pathogenesis of severe malaria.

TL;DR: This study suggests that NRG-1 attenuates ECM-associated brain inflammation and injuries and may represent a novel supportive therapy for the management of CM.

TL;DR: The vitamin D endocrine system reduces the risk for prolonged chlamydial infections through regulation of several proteins and that Leukocyte elastase inhibitor (LEI), an anti-inflammatory protein, was up-regulated.