John R. Dreier

TL;DR: It is shown that mTORC1 signalling increases the efficiency of proteasome-mediated protein degradation for both quality control and as a mechanism to supply substrate for sustained protein synthesis.

TL;DR: It is demonstrated that inhibition of mGluR5 corrects hyperactivity, seizures, and elevated de novo synaptic protein synthesis and results in the exacerbation of hyperactivity and epileptic phenotypes.

TL;DR: SNPs on chromosome 15q26.2 are associated with S-LAM, and chromatin and expression data suggest that this association may occur through effects on NR2F2 expression, which potentially plays an important role in S- LAM development.

TL;DR: It is demonstrated that loss of Tsc2 in pericytes generates HPC, the first mouse model of HPC reported, and distinctive perivascular tumors consisting of cells with oval nuclei and scant cytoplasm were identified in multiple sites in all T sc2ffFoxD1GC mice.

TL;DR: Loss of Tsc1 in fibroblasts in mice does not lead to a model of angiomyolipoma or lymphangioleiomyomatosis, which is quite different from the pathology seen in human TSC skin lesions.