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Edwin K. Silverman
Researcher at Brigham and Women's Hospital
Publications - 761
Citations - 52242
Edwin K. Silverman is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: COPD & Population. The author has an hindex of 115, co-authored 670 publications receiving 43901 citations. Previous affiliations of Edwin K. Silverman include University of Nebraska Medical Center & Hospital for Sick Children.
Papers
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Journal ArticleDOI
Genetic Epidemiology of COPD (COPDGene) Study Design
Elizabeth A. Regan,John E. Hokanson,James Murphy,Barry J. Make,David A. Lynch,Terri H. Beaty,Douglas Curran-Everett,Edwin K. Silverman,James D. Crapo +8 more
TL;DR: CPDGene will provide important new information about genetic factors in COPD, and will characterize the disease process using high resolution CT scans, which will potentially permit earlier diagnosis of this disease and may lead to the development of treatments to modify progression.
Journal ArticleDOI
Characterisation of COPD heterogeneity in the ECLIPSE cohort
Alvar Agusti,Peter M.A. Calverley,Bartolome R. Celli,Harvey O. Coxson,Lisa D. Edwards,David A. Lomas,William MacNee,Bruce E. Miller,S.I. Rennard,Edwin K. Silverman,Ruth Tal-Singer,Emiel F.M. Wouters,Julie C. Yates,Jørgen Vestbo +13 more
TL;DR: The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.
Journal ArticleDOI
Chronic obstructive pulmonary disease phenotypes: the future of COPD.
MeiLan K. Han,Alvar Agusti,Peter M.A. Calverley,Bartolome R. Celli,Gerard J. Criner,Jeffrey L. Curtis,Leonardo M. Fabbri,Jonathan G. Goldin,Paul W. Jones,William MacNee,Barry J. Make,Klaus F. Rabe,Stephen I. Rennard,Frank C. Sciurba,Edwin K. Silverman,Jørgen Vestbo,George R. Washko,Emiel F.M. Wouters,Fernando J. Martinez +18 more
TL;DR: This work proposes the following variation on this definition of COPD phenotypes: "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes (symptoms, exacerbations, response to therapy, rate of disease progression, or death)."
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Changes in forced expiratory volume in 1 second over time in copd
Jørgen Vestbo,Jørgen Vestbo,Lisa D. Edwards,Paul D. Scanlon,Julie C. Yates,Alvar Agusti,Per Bakke,Peter M.A. Calverley,Bartolome R. Celli,Harvey O. Coxson,Courtney Crim,David A. Lomas,William MacNee,Bruce E. Miller,Edwin K. Silverman,Ruth Tal-Singer,Emiel F.M. Wouters,Stephen I. Rennard +17 more
TL;DR: The rate of change in FEV(1) among patients with COPD is highly variable, with increased rates of decline among current smokers, patients with bronchodilator reversibility, and patients with emphysema.
Journal ArticleDOI
An Official American Thoracic Society Public Policy Statement: Novel Risk Factors and the Global Burden of Chronic Obstructive Pulmonary Disease
Mark D. Eisner,Nicholas R. Anthonisen,David B. Coultas,Nino Kuenzli,Rogelio Pérez-Padilla,Dirkje S. Postma,Isabelle Romieu,Edwin K. Silverman,John R. Balmes +8 more
TL;DR: It is concluded that specific genetic syndromes and occupational exposures were causally related to the development of COPD and a substantive burden of COPd is attributable to risk factors other than smoking.