J
John R. Farley
Researcher at Loma Linda University
Publications - 53
Citations - 3900
John R. Farley is an academic researcher from Loma Linda University. The author has contributed to research in topics: Alkaline phosphatase & Bone cell. The author has an hindex of 33, co-authored 53 publications receiving 3814 citations.
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Journal ArticleDOI
Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells.
TL;DR: Treatment with sodium fluoride increased proliferation and alkaline phosphatase activity of bone cells in vitro and increasedBone formation in embryonic calvaria at concentrations that stimulate bone formation in vivo.
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Androgens directly stimulate proliferation of bone cells in vitro
Christian H. Kasperk,Jon E. Wergedal,John R. Farley,Thomas A. Linkhart,Russell T. Turner,David J. Baylink +5 more
TL;DR: It is concluded that androgens can stimulate human and murine osteoblastic cell proliferation in vitro, and induce expression of the osteoblast-line differentiation marker ALP, presumably by an androgen receptor mediated mechanism.
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Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging.
V. Nicolas,A. Prewett,Paolo Bettica,Subburaman Mohan,Richard D. Finkelman,David J. Baylink,John R. Farley +6 more
TL;DR: A linear decline in the skeletal content of IGF-I (nanograms per mg protein) with donor age is found and that of TGF beta (r = -0.43; P < 0.001) in the total population.
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Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities.
Clifford J. Rosen,H.P. Dimai,D. Vereault,L.R. Donahue,Wesley G. Beamer,John R. Farley,Susan Linkhart,Thomas A. Linkhart,Subburaman Mohan,David J. Baylink +9 more
TL;DR: Analysis of circulatory and skeletal insulin-like growth factor-I and femoral bone mineral density in C3H and B6 progenitor strains and mice bred from subsequent F2 suggests that a possible mechanism for the difference in acquisition and maintenance of bone mass between these two inbred strains is related to systemic and skeletal IGF-I synthesis.
Journal ArticleDOI
Skeletal alkaline phosphatase activity as a bone formation index in vitro.
John R. Farley,David J. Baylink +1 more
TL;DR: It was found that ALP activity and 3[H]-hyp incorporation were coordinately increased from pH 5.5 to pH 7.2 and high and low pH, and when the exposure to effectors was limited to a preincubation, or when the low [Ca] data were excluded, a correlation was observed.