J
John R. White
Researcher at GlaxoSmithKline
Publications - 64
Citations - 8381
John R. White is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Chemokine & Receptor. The author has an hindex of 35, co-authored 63 publications receiving 8187 citations. Previous affiliations of John R. White include Indiana University & University of Connecticut Health Center.
Papers
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Journal ArticleDOI
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
Joseph C. Lee,Jeffrey T. Laydon,Peter C. McDonnell,Timothy Gallagher,Sanjay Kumar,David W. Green,Dean E. McNulty,M. J. Blumenthal,J. R. Heys,S. W. Landvatter,James E. Strickler,Megan M. McLaughlin,I. R. Siemens,Seth M. Fisher,George P. Livi,John R. White,Jerry L. Adams,Peter Young +17 more
TL;DR: Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds, suggesting that the CSBPs are critical for cytokine production.
Journal ArticleDOI
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration.
John R. White,Judithann M. Lee,Peter R. Young,Robert P. Hertzberg,Anthony J. Jurewicz,Margery A. Chaikin,Widdowson Katherine L,James J. Foley,Lenox D. Martin,Don E. Griswold,Henry M. Sarau +10 more
TL;DR: SB 225002 (N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea) is the first reported potent and selective non-peptide inhibitor of a chemokine receptor as mentioned in this paper.
Journal ArticleDOI
Programming the Grid with gLite
Erwin Laure,S-M Fisher,Akos Frohner,C. Grandi,Peter Z. Kunszt,A. Krenek,Olle Mulmo,F. Pacini,F. Prelz,John R. White,M. Barroso,P. Buncic,F. Hemmer,A. Di Meglio,Åke Edlund +14 more
TL;DR: The middleware (gLite) and services deployed on the EGEE Grid infrastructure are described and how applications can interface to them are explained.
Journal ArticleDOI
Glycan Array Screening Reveals a Candidate Ligand for Siglec-8
Bruce S. Bochner,Richard Alvarez,Padmaja Mehta,Nicolai V. Bovin,Ola Blixt,John R. White,Ronald L. Schnaar +6 more
TL;DR: It is concluded that Siglec-8 binds preferentially to the sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl, similar to how it binds to other sialic acid-binding lectin 8 ligands.
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Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.
TL;DR: The role of 1,2-diacylglycerol and activation of protein kinase C in specific granule release from rabbit neutrophils and the phosphorylation of the 50,000 molecular weight polypeptide produced by phorbl 12-myristate 13-acetate are discussed.