J
John T. Flaherty
Researcher at Johns Hopkins University
Publications - Â 75
Citations - Â 6214
John T. Flaherty is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Ischemia & Myocardial infarction. The author has an hindex of 33, co-authored 75 publications receiving 6148 citations. Previous affiliations of John T. Flaherty include Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
Direct measurement of free radical generation following reperfusion of ischemic myocardium
TL;DR: These experiments directly demonstrate that reactive oxygen-centered free radicals are generated in hearts during ischemia and that a burst of oxygen radical generation occurs within moments of reperfusion.
Journal ArticleDOI
American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes. A report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Committee).
Christopher P. Cannon,Alexander Battler,Ralph G. Brindis,Jafna L. Cox,Stephen G. Ellis,Nathan R. Every,John T. Flaherty,Robert A. Harrington,Harlan M. Krumholz,Maarten L. Simoons,Frans Van de Werf,William S. Weintraub,Kristi Mitchell,Susan L Morrisson,H. Vernon Anderson,David S. Cannom,W. Randolph Chitwood,Joaquin E. Cigarroa,Ruth L. Collins-Nakai,Raymond J. Gibbons,Frederick L. Grover,Paul A. Heidenreich,Bijoy K. Khandheria,Suzanne B. Knoebel,Harlan L Krumholz,David J. Malenka,Daniel B. Mark,Charles R. McKay,Eugene R. Passamani,Martha J. Radford,Ronald N Riner,Janice B. Schwartz,Richard E. Shaw,Richard J. Shemin,Douglas B. Van Fossen,Edward D. Verrier,Matthew W. Watkins,Dawn R. Phoubandith,Tori Furnelli +38 more
Journal ArticleDOI
Measurement and characterization of postischemic free radical generation in the isolated perfused heart.
Jay L. Zweier,Periannan Kuppusamy,R Williams,Barry K. Rayburn,Douglas R. Smith,Myron L. Weisfeldt,John T. Flaherty +6 more
TL;DR: Direct and spin trapping measurements of the time course and mechanisms of radical generation were performed in isolated perfused rabbit hearts, demonstrating that .O2- derived .OH, R., and ROO radicals are generated in postischemic myocardium.
Journal ArticleDOI
A randomized trial of intravenous tissue plasminogen activator for acute myocardial infarction with subsequent randomization to elective coronary angioplasty.
Alan D. Guerci,Gary Gerstenblith,Jeffrey A. Brinker,Nisha Chandra,Sidney O. Gottlieb,Raymond D. Bahr,James L. Weiss,Edward P. Shapiro,John T. Flaherty,David E. Bush,Paul H. Chew,Sheldon H. Gottlieb,Henry R. Halperin,Pamela Ouyang,Gary D. Walford,William R. Bell,Anil K. Fatterpaker,Michaelene P. Llewellyn,Eric J. Topol,Bernadine Healy,Cynthia O. Siu,Lewis C. Becker,Myron L. Weisfeldt +22 more
TL;DR: An approach to the treatment of acute myocardial infarction is supported that includes early intravenous administration of t-PA and deferred cardiac catheterization and coronary angioplasty and did not influence the ejection fraction at rest.
Journal ArticleDOI
Intravenous nitroglycerin in acute myocardial infarction.
TL;DR: In this article, the authors showed that intravenous nitroglycerin improved left ventricular function and decreased the extent of myocardial ischemia, and that longer infusion may act to preserve borderline ischemic myocardium and thus limit infarct size.