John T. Wei

TL;DR: Using laser-capture microdissection to isolate 101 cell populations, an integrative model of prostate cancer progression from benign epithelium to metastatic disease is generated and shows that analyzing gene expression signatures in the context of a compendium of molecular concepts is useful in understanding cancer biology.

TL;DR: In this paper, the authors employed high-throughput immunoblotting in order to interrogate tissue extracts derived from prostate cancer and identified 64 proteins altered in prostate cancer relative to benign prostate and 156 additional proteins that were altered in metastatic disease, revealing only 48%-64% concordance between protein and transcript levels.

TL;DR: While the number of outpatient visits for BPH increased consistently during the 1990s, there was a dramatic decrease in the use of transurethral prostatectomy, inpatient hospitalization and length of hospital stay for this condition in 2000.

TL;DR: Autoantibodies against peptides derived from prostate-cancer tissue could be used as the basis for a screening test for prostate cancer.

TL;DR: This work interrogated the expression of all ETS family members in prostate cancer profiling studies and identified marked overexpression of ETV4 in 2 of 98 cases, which defines a third molecular subtype of prostate cancer and supports the hypothesis that dysregulation of E TS family members through fusions with TMRPSS2 may be an initiating event in prostate cancers development.