抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

to be done in this area. Face recognition is a problem that scarcely clamoured for attention before the computer age but, having surfaced, has involved a wide range of techniques and has attracted the attention of some fine minds (David Mumford was a Fields Medallist in 1974). This singular application of mathematical modelling to a messy applied problem of obvious utility and importance but with no unique solution is a pretty one to share with students: perhaps, returning to the source of our opening quotation, we may invert Duncan's earlier observation, 'There is an art to find the mind's construction in the face!'.

Linear and nonlinear waves, by G. B. Whitham. Pp.636. £50. 1999. ISBN 0 471 35942 4 (Wiley).

To say that this is the best book on the quantum theory of fields is no praise, since to my knowledge it is the only book on this subject But it is a very good and most useful book The original was written in German and appeared in 1942 This is a translation with some minor changes A few remarks have been added, concerning meson theory and nuclear forces, also footnotes referring to modern work in this field, and finally an appendix on the symmetrization of the energy momentum tensor according to Belinfante Quantum Theory of Fields Prof Gregor Wentzel Translated from the German by Charlotte Houtermans and J M Jauch Pp ix + 224, (New York and London: Interscience Publishers, Inc, 1949) 36s

Quantum Theory of Fields

There is a special reason for reviewing this book at this time: it is the 50th edition of a compendium that is known and used frequently in most chemical and physical laboratories in many parts of the world. Surely, a publication that has been published for 56 years, withstanding the vagaries of science in this century, must have had something to offer. There is another reason: while the book is a standard fixture in most chemical and physical laboratories, including those in medical centers, it is not as frequently seen in the laboratories of physician's offices (those either in solo or group practice). I believe that the Handbook can be useful in those laboratories. One of the reasons, among others, is that the various basic items of information it offers may be helpful in new tests, either physical or chemical, which are continuously being published. The basic information may relate

Handbook of Chemistry and Physics

Water striders (Gerris remigis) have remarkable non-wetting legs that enable them to stand effortlessly and move quickly on water, a feature believed to be due to a surface-tension effect caused by secreted wax. We show here, however, that it is the special hierarchical structure of the legs, which are covered by large numbers of oriented tiny hairs (microsetae) with fine nanogrooves, that is more important in inducing this water resistance.

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Biophysics: Water-repellent legs of water striders

We present the results of a combined experimental and theoretical investigation of the motion of a sphere on an inclined flexible beam. A theoretical model based on Euler–Bernoulli beam theory is developed to describe the dynamics, and in the limit where the beam reacts instantaneously to the loading, we obtain exact solutions for the load trajectory and descent time. For the case of an initially horizontal beam, we calculate the period of the resulting oscillations. Theoretical predictions compare favourably with our experimental observations in this quasi-static regime. The time taken for descent along an elastic beam, the elastochrone, is shown to exceed the classical brachistochrone, the shortest time between two points in a gravitational field.

The Elastochrone: the descent time of a sphere on a flexible beam

We present the results of a theoretical investigation of the stability and collective vibrations of a two-dimensional hydrodynamic lattice comprised of millimetric droplets bouncing on the surface of a vibrating liquid bath. Using the theoretical model, we derive the linearized equations of motion describing the dynamics of a generic Bravais lattice, as encompasses all possible tilings of parallelograms in an infinite plane-filling array. Focusing on square and triangular lattice geometries, we demonstrate that for relatively low driving accelerations of the bath, only a subset of inter-drop spacings exist for which stable lattices may be achieved. The range of stable spacings is prescribed by the structure of the underlying wavefield. As the driving acceleration is increased progressively, the initially stationary lattices destabilize into coherent oscillatory motion. Our analysis yields both the instability threshold and the wavevector and polarization of the most unstable vibrational mode. The non-Markovian nature of the droplet dynamics renders the stability analysis of the hydrodynamic lattice more rich and subtle than that of its solid state counterpart.

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The Stability of a Hydrodynamic Bravais Lattice

The stability of rotating jets

Abstract We examine experimentally the influence of flexibility on the side-to-side fluttering motion of passive wings settling under the influence of gravity. Our results demonstrate the existence of an optimal flexibility that allows flexible wings to remain airborne twice as long as their rigid counterparts of identical mass and size. Flow visualization and measurements allow us to elucidate the role of flexibility in generating increased lift and wing circulation by shedding additional vorticity at the turning point. Theoretical scalings are derived from a reduced model of the flight dynamics and yield quantitative agreement with experiments. These scalings rationalize the strong positive correlation between flexibility and flight time. Our experimental results and theoretical scalings represent an ideal system for the validation of computational approaches to model biologically inspired fluid–structure interaction problems.

/pdf/flexibility-increases-lift-on-passive-fluttering-wings-5cuutexnkj.pdf

John W. M. Bush

Papers

The Elastochrone: the descent time of a sphere on a flexible beam

The Stability of a Hydrodynamic Bravais Lattice

The stability of rotating jets

Flexibility increases lift on passive fluttering wings

Non-local features of a hydrodynamic pilot-wave system