J
John W. Winslow
Researcher at Genentech
Publications - 50
Citations - 8222
John W. Winslow is an academic researcher from Genentech. The author has contributed to research in topics: Neurotrophic factors & Nerve growth factor. The author has an hindex of 27, co-authored 50 publications receiving 8100 citations. Previous affiliations of John W. Winslow include University of California, San Francisco.
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Journal ArticleDOI
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Heidi S. Phillips,Jeanne M. Hains,Mark Armanini,Gary R. Laramee,Steven A. Johnson,John W. Winslow +5 more
TL;DR: The possibility that decreased expression of BDNF may contribute to the progression of cell death in AD is suggested.
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Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.
Lucy R. Berkemeier,John W. Winslow,David R. Kaplan,Karoly Nikolics,David V. Goeddel,Arnon Rosenthal +5 more
TL;DR: NT-5 is structurally related to nerve growth factor and is expressed in embryonic as well as adult tissues and promotes the survival of peripheral sensory and sympathetic neurons and induces differentiation of the pheochromocytoma cell line PC12.
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Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.
TL;DR: Differences among subtypes in the affinities and proportions of such sites suggest the capacity of mAChR subtypes to interact differentially with the cellular effector‐coupling apparatus.
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Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes
E G Peralta,Avi Ashkenazi,Avi Ashkenazi,John W. Winslow,J. Ramachandran,J. Ramachandran,Daniel J. Capon +6 more
TL;DR: This work has investigated the ability of each subtype to regulate PI hydrolysis and adenylyl cyclase when expressed individually in a cell lacking endogenous mAChRs and results indicate that the different receptor subtypes are functionally specialized.
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Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.
Beat Knusel,John W. Winslow,Arnon Rosenthal,Louis E. Burton,Derice P. Seid,Karoly Nikolics,Franz Hefti +6 more
TL;DR: The findings suggest that BDNF stimulates survival or differentiation of other cells besides the cholinergic neurons, similar to NGF, which is well established as a neurotrophic factor for these cells.