Jon Skorve

TL;DR: It is discussed how a functionally mitochondrial-targeted compound, the modified fatty acid tetradecylthioacetic acid (TTA), can influence mitochondrial function and decrease the size of specific fat depots.

TL;DR: The results indicate that docosahexaenoic acid, in contrast to eicosapentaenoic Acid, does not inhibit the synthesis and secretion of triglycerides in the liver and emphasize the importance that stimulation of peroxisomal beta-oxidation by these n-3 fatty acids is not sufficient to decrease the serum levels of triglyceride.

TL;DR: The results suggest that the instant hypolipidemia in rats given EPA could be explained at least in part by a sudden increase in mitochondrial fatty acid oxidation, thereby reducing the availability of fatty acids for lipid synthesis in the liver for export, e.g., in the form of very low density lipoproteins, even before EPA induced peroxisomal fatty Acid oxidation, reduced triglyceride biosynthesis and diminished lipogenesis.

TL;DR: The present data indicate that there is a common site on the 60-S subunits for EF-1- and EF-2- stimulated GTPase activity and they suggest that abrin and ricin inhibit protein synthesis by modifying this site.

TL;DR: In this article, the pleiotropic effects of the 3-thia fatty acid tetradecylthioacetic acid have been revealed, showing that the biological responses to tetra