Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats
TLDR
The results indicate that docosahexaenoic acid, in contrast to eicosapentaenoic Acid, does not inhibit the synthesis and secretion of triglycerides in the liver and emphasize the importance that stimulation of peroxisomal beta-oxidation by these n-3 fatty acids is not sufficient to decrease the serum levels of triglyceride.About:
This article is published in Journal of Lipid Research.The article was published on 1993-01-01 and is currently open access. It has received 201 citations till now. The article focuses on the topics: Fatty acid & Docosahexaenoic acid.read more
Citations
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Journal ArticleDOI
Fish oil replacement in finfish nutrition
TL;DR: This review attempts to compile all principal information available regarding the effects of fish oil replacement for the diets of farmed finfish, analysing the findings using a comparative approach among different cultured fish species.
Journal ArticleDOI
The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation
TL;DR: In rodents, a PPAR alpha-mediated change in the expression of genes involved in fatty acid metabolism lies at the basis of the phenomenon of peroxisome proliferation, a pleiotropic cellular response, mainly limited to liver and kidney and which can lead to hepatocarcinogenesis.
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The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells.
TL;DR: In this article, the authors reported that incorporation into cellular lipids of docosahexaenoic acid (DHA), a specific fatty acid of the omega 3 family, decreases cytokine-induced expression of endothelial leukocyte adhesion molecules, secretion of inflammatory mediators, and leukocytes adhesion to cultured endothelial cells.
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Why do omega-3 fatty acids lower serum triglycerides?
TL;DR: As the vast majority of studies fed unphysiologically high doses of n-3 fatty acids, these findings in rats must be considered tentative, and the mechanism by which n- 3 fatty acids reduce triglyceride levels in humans remains speculative.
Journal ArticleDOI
Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
Yongsoon Park,William S. Harris +1 more
TL;DR: It is suggested that ω-3 FA supplementation accelerates chylomicron TG clearance by increasing LPL activity, and that EPA and DHA are equally effective.
References
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Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients with Hypertriglyceridemia
TL;DR: It is concluded that fish oils and fish may be useful components of diets for the treatment of hypertriglyceridemia.
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Enzymes of glycerolipid synthesis in eukaryotes.
TL;DR: Biosynthesis of Phosphatidylglycerol and Cardiolipin 474 Biosynthetic pathways for bis-Monoacylglyc erol-P 474 PHOSPHOGLYCERIDE MODIFICATION REACfIONS 475 Base Exchange Re reactions 475 Reacyiation Reactions 475
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Suppression by diets rich in fish oil of very low density lipoprotein production in man.
TL;DR: The highly polyunsaturated fatty acids in fish oils lower the plasma triglyceride concentration and presumptive evidence for substantial independent influx of LDL during the fish oil diet is found, based on the precursor-product relationship between the intermediate density lipoprotein and LDL apoprotein B specific radioactivity-time curves.
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The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils.
TL;DR: Fish oils contain fatty acids which may be metabolically unique and potentially useful in the control of both hypercholesterolemia and hypertriglyceridemia.
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Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase.
TL;DR: In conclusion, inhibition of acyl-CoA:1,2-diacylglycerol O-acyltransferase (EC 2.3.1.20) by eicosapentaenoic acid may be important for reduced synthesis and secretion of triacyl glycerol from the liver.