J
Jonas Petersen
Researcher at Goethe University Frankfurt
Publications - 8
Citations - 45
Jonas Petersen is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Neuropathic pain & Nociceptor. The author has an hindex of 3, co-authored 6 publications receiving 30 citations. Previous affiliations of Jonas Petersen include Witten/Herdecke University.
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Journal ArticleDOI
The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord.
Philip Tröster,Julia Haseleu,Jonas Petersen,Jonas Petersen,Oliver Drees,Achim Schmidtko,Achim Schmidtko,Frederick Schwaller,Gary R. Lewin,Gohar Ter-Avetisyan,York Winter,Stefanie Peters,Susanne Feil,Robert Feil,Fritz G. Rathjen,Hannes Schmidt +15 more
TL;DR: In this article, the authors investigate the functional consequences of axon bifurcation during adult stages of the human spinal cord and demonstrate that axon activation is critical for the processing of pain induced by heat or chemical stimuli.
Journal ArticleDOI
Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing.
Jonas Petersen,Evanthia Mergia,Lea Kennel,Oliver Drees,Rebecca Dorothee Steubing,Catherine Isabell Real,Wiebke Kallenborn-Gerhardt,Ruirui Lu,Andreas Friebe,Doris Koesling,Achim Schmidtko +10 more
TL;DR: Results indicate that cGMP produced by NO- GC1 or NO-GC2 in spinal dorsal horn neurons exert distinct, and partly opposing, functions in chronic pain processing.
Journal ArticleDOI
Rab7-a novel redox target that modulates inflammatory pain processing.
Wiebke Kallenborn-Gerhardt,Christine V. Möser,Jana E. Lorenz,Mirco Steger,Juliana Heidler,Reynir Scheving,Jonas Petersen,Lea Kennel,Cathrin Flauaus,Ruirui Lu,Aimee L. Edinger,Irmgard Tegeder,Gerd Geisslinger,Heinrich Heide,Ilka Wittig,Achim Schmidtko +15 more
TL;DR: A proteome screen for pain-dependent redox regulation using an OxICAT approach is performed, thereby identifying the small GTPase Rab7 as a redox-modified target during inflammatory pain in mice, and suggesting that red ox-dependent changes in Rab7 activity modulate inflammatory pain sensitivity.
Journal ArticleDOI
Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing.
Ruirui Lu,Katharina Metzner,Fangyuan Zhou,Cathrin Flauaus,Annika Balzulat,Patrick Engel,Jonas Petersen,Rebekka Ehinger,Anne E. Bausch,Peter Ruth,Robert Lukowski,Achim Schmidtko +11 more
TL;DR: In this paper, the authors used whole-cell patch-clamp recordings to identify P2X3/Slack signaling as a mechanism contributing to hypersensitivity after peripheral nerve injury and propose a potential novel strategy for treatment of neuropathic pain.
Journal ArticleDOI
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.
Wiebke Kallenborn-Gerhardt,Katharina Metzner,Ruirui Lu,Jonas Petersen,Miriam S. Kuth,Sandra Heine,Oliver Drees,Mandy H. Paul,Elvir Becirovic,Lea Kennel,Cathrin Flauaus,Tilman Gross,Gesine Wack,Stephan W. Hohmann,Dina Nemirovski,Domenico Del Turco,Martin Biel,Gerd Geisslinger,Stylianos Michalakis,Achim Schmidtko +19 more
TL;DR: The data suggest that CNGB1-positive CNG channels specifically contribute to neuropathic pain processing after peripheral nerve injury, and provide evidence to supportCNGB1 as a downstream mediator of cAMP signaling in pain pathways.