J
Jonathan D. Silk
Researcher at John Radcliffe Hospital
Publications - 26
Citations - 2247
Jonathan D. Silk is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Natural killer T cell & Antigen. The author has an hindex of 18, co-authored 24 publications receiving 2115 citations. Previous affiliations of Jonathan D. Silk include University of Oxford & Ludwig Institute for Cancer Research.
Papers
More filters
Journal ArticleDOI
NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells.
Ian F. Hermans,Jonathan D. Silk,Uzi Gileadi,Mariolina Salio,Bini Mathew,Gerd Ritter,Richard R. Schmidt,Adrian L. Harris,Lloyd Old,Vincenzo Cerundolo +9 more
TL;DR: iNKT cells exert a significant influence on the efficacy of immune responses to soluble Ag by modulating DC function, and these responses resisted challenge with OVA-expressing tumors.
Journal ArticleDOI
Harnessing invariant NKT cells in vaccination strategies
TL;DR: Evidence indicating that invariant natural killer T (iNKT) cells can positively modulate dendritic cells and B cells, and that their pharmacological activation in the presence of antigenic proteins can enhance antigen-specific B- and T-cell responses is discussed.
Journal ArticleDOI
Biology of CD1- and MR1-restricted T cells.
TL;DR: The most recent events in the field are described, with particular emphasis on structural and functional aspects of lipid presentation by CD1 molecules, the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation.
Journal ArticleDOI
The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo
Ian F. Hermans,Jonathan D. Silk,Jianping Yang,Michael J. Palmowski,Uzi Gileadi,Corinna McCarthy,Mariolina Salio,Franca Ronchese,Vincenzo Cerundolo +8 more
TL;DR: It is shown that this assay, referred to as the VITAL assay, can be used to assess cytotoxic activity of CTL and iNKT cells in vivo and in vitro, and is a sensitive technique allowing analysis of complex multi-epitope responses.
Journal ArticleDOI
Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.
Jonathan D. Silk,Ian F. Hermans,Uzi Gileadi,Tsung Wen Chong,Dawn Shepherd,Mariolina Salio,Bini Mathew,Richard R. Schmidt,Sarah Jane Lunt,Kaye J. Williams,Ian J. Stratford,Adrian L. Harris,Vincenzo Cerundolo +12 more
TL;DR: The therapeutic potential of iNKT cell ligands in vaccination strategies, particularly "heterologous prime-boost" strategies against tumors, are highlighted, and evidence that iN KT cell stimulation may be exploited in the development of oral vaccines is provided.