U
Uzi Gileadi
Researcher at University of Oxford
Publications - 62
Citations - 4949
Uzi Gileadi is an academic researcher from University of Oxford. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 29, co-authored 52 publications receiving 4591 citations. Previous affiliations of Uzi Gileadi include John Radcliffe Hospital.
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Journal ArticleDOI
Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport.
Stephen C. Hyde,Paul Emsley,Michael J. Hartshorn,Michael M. Mimmack,Uzi Gileadi,Stephen R. Pearce,Stephen R. Pearce,Maurice P. Gallagher,Maurice P. Gallagher,Deborah R. Gill,Roderick E. Hubbard,Christopher F. Higgins +11 more
TL;DR: A tertiary structure model of the ATP-binding cassettes characteristic of this class of transport system is presented, based on similarities between the predicted secondary structures of members of this family and the previously determined structure of adenylate kinase.
Journal ArticleDOI
NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells.
Ian F. Hermans,Jonathan D. Silk,Uzi Gileadi,Mariolina Salio,Bini Mathew,Gerd Ritter,Richard R. Schmidt,Adrian L. Harris,Lloyd Old,Vincenzo Cerundolo +9 more
TL;DR: iNKT cells exert a significant influence on the efficacy of immune responses to soluble Ag by modulating DC function, and these responses resisted challenge with OVA-expressing tumors.
Journal ArticleDOI
Binding protein-dependent transport systems.
Christopher F. Higgins,Stephen C. Hyde,M. M. Mimmack,Uzi Gileadi,Deborah R. Gill,Maurice P. Gallagher +5 more
TL;DR: The current state of knowledge on the structure and function of the protein components of these transporters, the mechanism by which transport is mediated, and the role of ATP in the transport process are reviewed.
Journal ArticleDOI
Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis.
S C Hyde,Kevin W Southern,Uzi Gileadi,EM Fitzjohn,KA Mofford,BE Waddell,Gooi Hc,C. A. Goddard,Hannavy K,SE Smyth,Egan Jj,F. Sorgi,Leaf Huang,Alan W. Cuthbert,Martin J. Evans,William H. Colledge,Christopher F. Higgins,A K Webb,Deborah R. Gill +18 more
TL;DR: The efficacy measures suggest that unlike high doses of recombinant adenoviral vectors, DNA/liposomes can be successfully re-administered without apparent loss of efficacy.
Journal ArticleDOI
The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo
Ian F. Hermans,Jonathan D. Silk,Jianping Yang,Michael J. Palmowski,Uzi Gileadi,Corinna McCarthy,Mariolina Salio,Franca Ronchese,Vincenzo Cerundolo +8 more
TL;DR: It is shown that this assay, referred to as the VITAL assay, can be used to assess cytotoxic activity of CTL and iNKT cells in vivo and in vitro, and is a sensitive technique allowing analysis of complex multi-epitope responses.