Jonathan Ollivier

TL;DR: The remarkable normal tissue sparing afforded by FLASH may someday provide heretofore unrealized opportunities for dose escalation to the tumor bed, capabilities that promise to hasten the translation of this groundbreaking irradiation modality into clinical practice.

TL;DR: The main data supporting the clinical translation of FLASH-RT is summarized, the key irradiation parameters and the potential technologies needed for a successful clinical translation are explored and its feasibility is explored.

TL;DR: The present results show that FLASH-RT delivered with hypofractionated regimens is able to spare the normal brain from radiation-induced toxicities without compromising tumor cure, and provides an initial framework for future clinical applications of FLash-RT.

TL;DR: In this paper , the Physico-chemical and biological response to conventional and UHDR electron and proton beams was investigated, along with conventional photons, and the temporal structure and nature of the beam affected both, with electron beam at ≥ 1400 Gy/s and proion beam at 0.1 and 1260 Gy/m found to be isoefficient at sparing zebrafish embryos.

TL;DR: TAT-RasGAP317–326 is a radiosensitized agent that acts on carcinoma cells and its radiosensitizing effect might be mediated, at least in part, by the enhancement of mitotic cell death.