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Patrik Gonçalves Jorge
Researcher at University of Lausanne
Publications - 22
Citations - 1365
Patrik Gonçalves Jorge is an academic researcher from University of Lausanne. The author has contributed to research in topics: Dosimetry & Medicine. The author has an hindex of 8, co-authored 14 publications receiving 515 citations.
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Journal ArticleDOI
Treatment of a first patient with FLASH-radiotherapy.
Jean Bourhis,Wendy Jeanneret Sozzi,Patrik Gonçalves Jorge,Olivier Gaide,Claude Bailat,F. Duclos,David Patin,Mahmut Ozsahin,François Bochud,Jean-François Germond,Raphaël Moeckli,Marie-Catherine Vozenin +11 more
TL;DR: This first FLash-RT treatment was feasible and safe with a favorable outcome both on normal skin and the tumor, and prompt to further clinical evaluation of FLASH-RT.
Journal ArticleDOI
Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.
Pierre Montay-Gruel,Munjal M. Acharya,Kristoffer Petersson,Leila Alikhani,Chakradhar Yakkala,Barrett D. Allen,Jonathan Ollivier,Benoit Petit,Patrik Gonçalves Jorge,Amber R. Syage,Thuan Nguyen,Al Anoud D. Baddour,Celine Lu,Paramvir Singh,Raphaël Moeckli,François Bochud,Jean François Germond,Pascal Froidevaux,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin,Charles L. Limoli +21 more
TL;DR: The remarkable normal tissue sparing afforded by FLASH may someday provide heretofore unrealized opportunities for dose escalation to the tumor bed, capabilities that promise to hasten the translation of this groundbreaking irradiation modality into clinical practice.
Journal ArticleDOI
Clinical translation of FLASH radiotherapy: Why and how?
Jean Bourhis,Pierre Montay-Gruel,Patrik Gonçalves Jorge,Claude Bailat,Benoit Petit,Jonathan Ollivier,Wendy Jeanneret-Sozzi,Mahmut Ozsahin,François Bochud,Raphaël Moeckli,Jean-François Germond,Marie-Catherine Vozenin +11 more
TL;DR: The main data supporting the clinical translation of FLASH-RT is summarized, the key irradiation parameters and the potential technologies needed for a successful clinical translation are explored and its feasibility is explored.
Journal ArticleDOI
Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice.
Pierre Montay-Gruel,Munjal M. Acharya,Patrik Gonçalves Jorge,Benoit Petit,Ioannis G. Petridis,Philippe Fuchs,Ron Leavitt,Kristoffer Petersson,Maude Gondré,Jonathan Ollivier,Raphaël Moeckli,François Bochud,Claude Bailat,Jean Bourhis,Jean François Germond,Charles L. Limoli,Marie-Catherine Vozenin +16 more
TL;DR: The present results show that FLASH-RT delivered with hypofractionated regimens is able to spare the normal brain from radiation-induced toxicities without compromising tumor cure, and provides an initial framework for future clinical applications of FLash-RT.
Journal ArticleDOI
Dosimetric and preparation procedures for irradiating biological models with pulsed electron beam at ultra-high dose-rate.
Patrik Gonçalves Jorge,Maud Jaccard,Kristoffer Petersson,Maude Gondré,Maria Teresa Durán,Laurent Desorgher,Jean François Germond,Philippe Liger,Marie-Catherine Vozenin,Jean Bourhis,François Bochud,Raphaël Moeckli,Claude Bailat +12 more
TL;DR: The method is based on validated absolute dosimeters and extends their use to routine FLASH irradiations and developed the requirements needed for workflows of preclinical and clinical studies.