J
Jonathan S. Boomer
Researcher at Washington University in St. Louis
Publications - 34
Citations - 3234
Jonathan S. Boomer is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Asthma & Bronchiolitis. The author has an hindex of 17, co-authored 29 publications receiving 2749 citations. Previous affiliations of Jonathan S. Boomer include Rosalind Franklin University of Medicine and Science & Baylor College of Medicine.
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Journal ArticleDOI
Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
Journal ArticleDOI
Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: In this article, rapid postmortem spleen and lung tissue harvest was performed at the bedsides of 40 patients who died in intensive care units (ICUs) of academic medical centers with active severe sepsis to characterize their immune status at the time of death (2009-2011).
Journal ArticleDOI
Reactivation of Multiple Viruses in Patients with Sepsis
Andrew H. Walton,Jared T. Muenzer,David Rasche,Jonathan S. Boomer,Bryan Sato,Bernard H. Brownstein,Alexandre Pachot,Terrence L. Brooks,Elena Deych,William D. Shannon,Jonathan M. Green,Gregory A. Storch,Richard S. Hotchkiss +12 more
TL;DR: It is hypothesized that reactivation of latent viruses occurred with prolonged sepsis thereby providing evidence of clinically-relevant immunosuppression and potentially providing a means to serially-monitor patients' immune status and if viral loads are markedly elevated, they may contribute to morbidity and mortality.
Journal ArticleDOI
The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?
TL;DR: The future of immune therapy in sepsis will necessitate identification of the immunologic phase using clinical and laboratory parameters as well as biomarkers of innate and adaptive immunity.
Journal ArticleDOI
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
Shawn A. Mahmud,Luke S. Manlove,Heather Schmitz,Yan Xing,Yanyan Wang,David L. Owen,Jason M. Schenkel,Jonathan S. Boomer,Jonathan M. Green,Hideo Yagita,Hongbo Chi,Kristin A. Hogquist,Michael A. Farrar +12 more
TL;DR: This paper found that Treg cell progenitors had high expression of the TNFRSF members GITR, OX40 and TNFR2, which correlated directly with the signal strength of T cell antigen receptor (TCR).