Jonathan T. Henry

TL;DR: The current state of knowledge of the structural foundations and evolution of ligand recognition and binding by Per-Arnt-Sim domains is synthesized.

TL;DR: The experimental and theoretical analysis reveals a simple physical principle governing these complex biological processes: a single temperature-dependent scale of cellular time governs the stochastic dynamics of growth and division in balanced growth conditions.

TL;DR: Two cell cycle regulatory signals, ppGpp and polyphosphate (polyP), are identified that inhibit the swarmer-to-stalked transition in both complex and glucose-exhausted media, thereby increasing the proportion ofSwarmer cells in mixed culture and providing evidence that ppGopp and polyP are cell-type-specific developmental regulators.

TL;DR: Using chromatin immunoprecipitation-DNA sequencing (ChIP-Seq) and genome-wide expression profiling, this work demonstrates that PhoB is induced to regulate nearly 50 genes under phosphate-starved conditions and favors a model in which PhoU affects intracellular phosphate accumulation, possibly through the high-affinity phosphate transporter.

TL;DR: Seven cysteine-substituted subunits are created by site-directed mutagenesis, choosing residues in the putative morantel binding site with the aid of structural homology models and it is concluded that the four residues showing MTS effects contribute to the morantels binding site.