J
Jonathan W. Simons
Researcher at Prostate Cancer Foundation
Publications - 139
Citations - 24219
Jonathan W. Simons is an academic researcher from Prostate Cancer Foundation. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 54, co-authored 139 publications receiving 23331 citations. Previous affiliations of Jonathan W. Simons include Johns Hopkins University School of Medicine & Emory University.
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Journal Article
Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases
Hua Zhong,Angelo M. De Marzo,Erik Laughner,Michael Lim,David A Hilton,David Zagzag,Peter Buechler,William B. Isaacs,Gregg L. Semenza,Jonathan W. Simons +9 more
TL;DR: The first clinical data indicating that HIF-1alpha may play an important role in human cancer progression are provided, indicating adaptations to a hypoxic microenvironment that are correlated with tumor invasion, metastasis, and lethality.
Journal ArticleDOI
Identification of a chromosome 18q gene that is altered in colorectal cancers
Eric R. Fearon,Kathleen R. Cho,Janice M. Nigro,Scott E. Kern,Jonathan W. Simons,J. Michael Ruppert,Stanley R. Hamilton,Antonette C. Preisinger,Giles Thomas,Kenneth W. Kinzler,Bert Vogelstein +10 more
TL;DR: A contiguous stretch of DNA comprising 370 kilobase pairs has now been cloned from a region of chromosome 18q suspected to reside near the DCC gene, which may play a role in the pathogenesis of human colorectal neoplasia, perhaps through alteration of the normal cell-cell interactions controlling growth.
Journal Article
Modulation of Hypoxia-inducible Factor 1α Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics
Hua Zhong,Kelly Chiles,David M. Feldser,Erik Laughner,Colleen Hanrahan,Maria Magdalena Georgescu,Jonathan W. Simons,Gregg L. Semenza +7 more
TL;DR: It is demonstrated that in human prostate cancer cells, basal-, growth factor- and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) alpha, the regulated subunit of the transcription factor Hif-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively.
Journal ArticleDOI
The genomic complexity of primary human prostate cancer
Michael F. Berger,Michael F. Berger,Michael S. Lawrence,Francesca Demichelis,Yotam Drier,Kristian Cibulskis,Andrey Sivachenko,Andrea Sboner,Raquel Esgueva,Dorothee Pflueger,Carrie Sougnez,Robert C. Onofrio,Scott L. Carter,Kyung Park,Lukas Habegger,Lauren Ambrogio,Timothy Fennell,Melissa Parkin,Gordon Saksena,Douglas Voet,Alex H. Ramos,Alex H. Ramos,Trevor J. Pugh,Trevor J. Pugh,Jane Wilkinson,Sheila Fisher,Wendy Winckler,Scott Mahan,Kristin G. Ardlie,Jennifer Baldwin,Jonathan W. Simons,Naoki Kitabayashi,Theresa Y. MacDonald,Philip W. Kantoff,Lynda Chin,Stacey Gabriel,Mark Gerstein,Todd R. Golub,Todd R. Golub,Todd R. Golub,Matthew Meyerson,Matthew Meyerson,Ashutosh Tewari,Eric S. Lander,Eric S. Lander,Eric S. Lander,Gad Getz,Mark A. Rubin,Levi A. Garraway,Levi A. Garraway +49 more
TL;DR: In this paper, the authors presented the complete sequence of seven primary human prostate cancers and their paired normal counterparts and revealed previously unknown balanced rearrangements, at which multiple intra-and inter-chromosomal loci exchange their breakpoint arms without any loss of genetic material.
Journal ArticleDOI
In vivo molecular and cellular imaging with quantum dots.
TL;DR: A new structural design involves encapsulating luminescent QDs with amphiphilic block copolymers and linking the polymer coating to tumor-targeting ligands and drug delivery functionalities, which raised new possibilities for ultrasensitive and multiplexed imaging of molecular targets in living cells, animal models and possibly in humans.