Jong Il Kim

TL;DR: The first large scale RNA sequencing study of lung adenocarcinoma is presented, demonstrating its power to identify somatic point mutations as well as transcriptional variants such as gene fusions, alternative splicing events, and expression outliers.

TL;DR: It is demonstrated that a subset of NSCLCs could be caused by a fusion of KIF5B and RET, and suggested the chimeric oncogene as a promising molecular target for the personalized diagnosis and treatment of lung cancer.

TL;DR: It is concluded that HSP70 acts as a strong suppressor of apoptosis acting downstream of cytochrome c release and upstream of caspase-3 activation.

TL;DR: The total genomic content of currently known common human CNVs is likely smaller than previously thought, and approximately 8% of the CNV regions observed in multiple individuals exhibited genomic architectural complexity in the form of smaller CNVs within larger ones and CNVs with interindividual variation in breakpoints.

TL;DR: It was found that exposure to amyloid-β triggers acute microglial inflammation accompanied by metabolic reprogramming from oxidative phosphorylation to glycolysis, and it was shown that metabolic boosting with recombinant interferon-γ treatment reversed the defective Glycolytic metabolism and inflammatory functions of microglia, thereby mitigating the AD pathology of 5XFAD mice.