Thomas Bleazard

TL;DR: The first large scale RNA sequencing study of lung adenocarcinoma is presented, demonstrating its power to identify somatic point mutations as well as transcriptional variants such as gene fusions, alternative splicing events, and expression outliers.

TL;DR: It is demonstrated that a subset of NSCLCs could be caused by a fusion of KIF5B and RET, and suggested the chimeric oncogene as a promising molecular target for the personalized diagnosis and treatment of lung cancer.

TL;DR: This study develops a feeder-free, long-term three-dimensional culture technique for hAT2 cells derived from primary human lung tissue, and investigates infection response to SARS-CoV-2, revealing rapid viral replication and the increased expression of interferon-associated genes and pro-inflammatory genes in infected hat2 cells, indicating robust endogenous innate immune response.

TL;DR: It is found thatDNA methylation gain during reprogramming occurs gradually, while loss is achieved only at the ESC-like state, and the crucial role that DNA methylation plays as an epigenetic switch driving somatic cells to pluripotency is revealed.

TL;DR: It is shown that the most commonly used functional enrichment test is inappropriate for the analysis of sets of genes targeted by miRNAs, and is argued against continued use of the standard functional enrichment method for miRNA targets.