J
Jong Seung Lee
Researcher at Yonsei University
Publications - 24
Citations - 915
Jong Seung Lee is an academic researcher from Yonsei University. The author has contributed to research in topics: Neural stem cell & Transplantation. The author has an hindex of 15, co-authored 22 publications receiving 604 citations.
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Journal ArticleDOI
Multiscale, hierarchically patterned topography for directing human neural stem cells into functional neurons.
Kisuk Yang,Hyunjung Jung,Hak Rae Lee,Jong Seung Lee,Su Ran Kim,Ki Yeong Song,Eunji Cheong,Joona Bang,Sung Gap Im,Seung Woo Cho +9 more
TL;DR: A hierarchically patterned substrate (HPS) platform that can synergistically enhance the differentiation of human NSCs (hNSCs) by simultaneously providing microscale and nanoscale spatial controls to facilitate the alignment of the cytoskeleton and the formation of focal adhesions is developed.
Journal ArticleDOI
Electrospun Silk Fibroin Nanofibrous Scaffolds with Two-Stage Hydroxyapatite Functionalization for Enhancing the Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells
Eunkyung Ko,Jong Seung Lee,Hyunryung Kim,Sung Yeun Yang,Dasom Yang,Kisuk Yang,Jiyong Lee,Jisoo Shin,Hee Seok Yang,WonHyoung Ryu,Seung Woo Cho +10 more
TL;DR: Two-stage HAp-functionalized SF scaffolds significantly promoted the osteogenic differentiation of TAZ-transfected hADMSCs in vitro and enhanced mineralized bone formation in a critical-sized calvarial bone defect model.
Journal ArticleDOI
Graphene Oxide Hierarchical Patterns for the Derivation of Electrophysiologically Functional Neuron-like Cells from Human Neural Stem Cells.
Kisuk Yang,Jaehong Lee,Jong Seung Lee,Dayeong Kim,Gyeong Eon Chang,Jungmok Seo,Eunji Cheong,Taeyoon Lee,Seung Woo Cho +8 more
TL;DR: This study demonstrates that GPS could be an effective culture platform for the generation of functional neuron-like cells from hNSCs, providing potent therapeutics for treating neurodegenerative diseases and neuronal disorders.
Journal ArticleDOI
Electroconductive nanoscale topography for enhanced neuronal differentiation and electrophysiological maturation of human neural stem cells.
Kisuk Yang,Seung Jung Yu,Jong Seung Lee,Hak Rae Lee,Gyeong Eon Chang,Jungmok Seo,Taeyoon Lee,Eunji Cheong,Sung Gap Im,Seung Woo Cho +9 more
TL;DR: The present work suggests that an electroconductive nanopatterned substrate can serve as an effective culture platform for deriving highly mature, functional neuronal lineage cells from stem cells.
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Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system.
Kisuk Yang,Hyun Ji Park,Sewoon Han,Joan Lee,Eunkyung Ko,Jin Kim,Jong Seung Lee,Ji Hea Yu,Ki Yeong Song,Eunji Cheong,Sung Rae Cho,Seok Chung,Seung Woo Cho +12 more
TL;DR: The presented 3D microfluidic array device can provide an efficient co-culture platform and provide an environment for paracrine signals from transplanted stem cells to control endogenous neuronal behaviors in vivo.