Joo Ok Min

TL;DR: This work shows that glial gamma aminobutyric acid (GABA) is produced by monoamine oxidase B (MAOB), utilizing a polyamine, putrescine, to synthesize glial GABA, which is released to mediate tonic inhibition in the cerebellum and striatum.

TL;DR: The findings indicate that astrocytes are the key player in motor coordination through tonic GABA release by modulating neuronal excitability and could be a good therapeutic target for various movement and psychiatric disorders, which show a disturbed excitation/inhibition balance.

TL;DR: It is suggested that tumor necrosis factor α (TNF-α), a key inflammatory cytokine, alters the neural activity of the cerebellar Purkinje cells (PCs) by facilitating gliotransmission in the juvenile male rat cerebellum by triggering glutamate release in Bergmann glia.

TL;DR: It is demonstrated that pronuclear injection of lentiviral vectors expressing small hairpin RNAs (shRNAs) that silence the expression of specific genes can be used to generate knockdown mice and suggested that the Best1 knockdown mouse can be a useful tool for studying Best1 gene function.

TL;DR: Autophagy-targeting Chimera (AUTOTACM) as mentioned in this paper is a macro-autophagy based targeted protein degradation (TPD) platform developed in earlier studies.