Joon Ho Cho

TL;DR: Memory dysfunction occurs in infected mice exposed to acute stress, while in the germ-free setting memory is altered at baseline, suggesting the intestinal microbiota influences the ability to form memory.

TL;DR: Girardin et al. as mentioned in this paper reported that early production of IL-17A by CD4+ T helper cells is important for host defense against Citrobacter and Salmonella infection.

TL;DR: It is found that Citrobacter and Salmonella infection triggered early IL-17 production, which was crucial for host defense and was mediated by CD4+ T helper cells, and imprinting by the intestinal microbiota was fully required for the generation of iTH17 responses.

TL;DR: The findings emphasize the importance of using F2 littermate controls to minimize environmental sources of variation in microbial analyses, to establish baseline conditions for host-microbe homeostasis in Nod-deficient mice and to strengthen models for testing factors contributing to microbial dysbiosis associated with IBD.

TL;DR: Nod1 and Nod2 can modulate inflammation and mediate efficient clearance of bacteria from the mucosal tissue during Salmonella colitis, but their role is dependent on the expression of the SPI-2 TTSS.