L
Lionel Le Bourhis
Researcher at French Institute of Health and Medical Research
Publications - 63
Citations - 7908
Lionel Le Bourhis is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 30, co-authored 46 publications receiving 6923 citations. Previous affiliations of Lionel Le Bourhis include Sorbonne & Pasteur Institute.
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Journal ArticleDOI
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Leonardo H. Travassos,Leticia A.M. Carneiro,Mahendrasingh Ramjeet,Seamus Hussey,Seamus Hussey,Yun Gi Kim,Joao G. Magalhaes,Linda Yuan,Fraser Soares,Evelyn Chea,Lionel Le Bourhis,Ivo G Boneca,Abdelmounaaim Allaoui,Nicola L. Jones,Gabriel Núñez,Stephen E. Girardin,Dana J. Philpott +16 more
TL;DR: The results link bacterial sensing by Nod proteins to the induction of autophagy and provide a functional link between Nod2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn's disease.
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Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells
Mathilde Dusseaux,Mathilde Dusseaux,Emmanuel Martin,Emmanuel Martin,Nacer Serriari,Isabelle Peguillet,Virginie Premel,Virginie Premel,Delphine Louis,Maud Milder,Lionel Le Bourhis,Lionel Le Bourhis,Claire Soudais,Claire Soudais,Emmanuel Treiner,Olivier Lantz,Olivier Lantz +16 more
TL;DR: The gut-liver homing characteristics, high expression of ABCB1, and ability to secrete interleukin-17 probably participate in the antibacterial properties of MAIT cells.
Journal ArticleDOI
Antimicrobial activity of mucosal-associated invariant T cells
Lionel Le Bourhis,Emmanuel Martin,Emmanuel Martin,Isabelle Peguillet,Isabelle Peguillet,Amélie Guihot,Nathalie Froux,Maxime Coré,Maxime Coré,Eva Lévy,Eva Lévy,Mathilde Dusseaux,Mathilde Dusseaux,Vanina Meyssonnier,Virginie Premel,Virginie Premel,Charlotte Ngo,Béatrice Riteau,Livine Duban,Livine Duban,Delphine Robert,Delphine Robert,Shouxiong Huang,Martin Rottman,Claire Soudais,Claire Soudais,Olivier Lantz,Olivier Lantz,Olivier Lantz +28 more
TL;DR: MAIT cells are evolutionarily conserved innate-like lymphocytes that sense and help fight off microbial infection and protect against infection by Mycobacterium abscessus or Escherichia coli.
Journal ArticleDOI
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.
Ai Ing Lim,Ai Ing Lim,Ai Ing Lim,Yan Li,Yan Li,Silvia Lopez-Lastra,Silvia Lopez-Lastra,Silvia Lopez-Lastra,Ralph Stadhouders,Franziska Paul,Armanda Casrouge,Armanda Casrouge,Nicolas Serafini,Nicolas Serafini,Anne Puel,Anne Puel,Jacinta Bustamante,Jacinta Bustamante,Laura Surace,Laura Surace,Guillemette Masse-Ranson,Guillemette Masse-Ranson,Eyal David,Helene Strick-Marchand,Helene Strick-Marchand,Lionel Le Bourhis,Roberto Cocchi,Davide Topazio,Paolo Graziano,Lucia Anna Muscarella,Lars Rogge,Xavier Norel,Jean-Michel Sallenave,Matthieu Allez,Thomas Graf,Rudi W. Hendriks,Jean-Laurent Casanova,Ido Amit,Hans Yssel,James P. Di Santo,James P. Di Santo +40 more
TL;DR: The results support a model of tissue ILC differentiation ("ILC-poiesis"), whereby diverse ILC subsets are generated in situ from systemically distributed ILCPs in response to local environmental signals.
Journal ArticleDOI
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells
Maria Kaparakis,Lynne Turnbull,Leticia A.M. Carneiro,Stephen Firth,Harold A. Coleman,Helena C. Parkington,Lionel Le Bourhis,Abdulgader Karrar,Jérôme Viala,Johnson Mak,Melanie L. Hutton,John K. Davies,Peter J Crack,Paul J. Hertzog,Dana J. Philpott,Stephen E. Girardin,Cynthia B. Whitchurch,Richard L. Ferrero +17 more
TL;DR: It is proposed that OMVs released by bacteria in vivo may promote inflammation and pathology in infected hosts via a novel mechanism involving outer membrane vesicles (OMVs), whereby Gram‐negative bacteria deliver peptidoglycan to cytosolic NOD1.