J
Joao G. Magalhaes
Researcher at PSL Research University
Publications - 41
Citations - 5535
Joao G. Magalhaes is an academic researcher from PSL Research University. The author has contributed to research in topics: Innate immune system & NOD1. The author has an hindex of 32, co-authored 40 publications receiving 5022 citations. Previous affiliations of Joao G. Magalhaes include University of Toronto & French Institute of Health and Medical Research.
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Journal ArticleDOI
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Leonardo H. Travassos,Leticia A.M. Carneiro,Mahendrasingh Ramjeet,Seamus Hussey,Seamus Hussey,Yun Gi Kim,Joao G. Magalhaes,Linda Yuan,Fraser Soares,Evelyn Chea,Lionel Le Bourhis,Ivo G Boneca,Abdelmounaaim Allaoui,Nicola L. Jones,Gabriel Núñez,Stephen E. Girardin,Dana J. Philpott +16 more
TL;DR: The results link bacterial sensing by Nod proteins to the induction of autophagy and provide a functional link between Nod2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn's disease.
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Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity
Jörg H. Fritz,Lionel Le Bourhis,Gernot Sellge,Joao G. Magalhaes,Hafida Fsihi,Thomas A. Kufer,Cathy Collins,Jérôme Viala,Richard L. Ferrero,Stephen E. Girardin,Dana J. Philpott +10 more
TL;DR: Findings show that innate immune sensing of peptidoglycan by Nod1 is key for priming antigen-specific T cell immunity and subsequent antibody responses in vivo and highlights Nod 1 as a key innate immune trigger in the local tissue microenvironment that drives the development of adaptive immunity.
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NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production
Ivan Tattoli,Leticia A.M. Carneiro,Muguette Jéhanno,Joao G. Magalhaes,Youmin Shu,Dana J. Philpott,Damien Arnoult,Stephen E. Girardin +7 more
TL;DR: NLRX1 is identified as a NLR that contributes to the link between ROS generation at the mitochondria and innate immune responses, and amplified NF‐κB‐dependent and JUN amino‐terminal kinases‐dependent signalling.
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Identification of an innate T helper type 17 response to intestinal bacterial pathogens
Kaoru Geddes,Stephen Rubino,Joao G. Magalhaes,Catherine J. Streutker,Lionel Le Bourhis,Joon Ho Cho,Susan J. Robertson,Connie J. Kim,Rupert Kaul,Dana J. Philpott,Stephen E. Girardin +10 more
TL;DR: Girardin et al. as mentioned in this paper reported that early production of IL-17A by CD4+ T helper cells is important for host defense against Citrobacter and Salmonella infection.
Journal ArticleDOI
NOD1 Activators Link Innate Immunity to Insulin Resistance
Jonathan D. Schertzer,Akhilesh K. Tamrakar,Joao G. Magalhaes,Sandra Pereira,Philip J. Bilan,Morgan D. Fullerton,Zhi Liu,Gregory R. Steinberg,Adria Giacca,Dana J. Philpott,Amira Klip +10 more
TL;DR: Acute activation of NOD proteins by mimetics of bacterial PGNs causes whole-body insulin resistance, bolstering the concept that innate immune responses to distinctive bacterial cues directly lead to insulin resistance.