Jordan T Feigerle

TL;DR: A technology called iPOND (isolation of proteins on nascent DNA) is described to analyze proteins at active and damaged replication forks at high resolution and is established as a useful methodology to study DNA replication and chromatin maturation.

TL;DR: The mechanism through which TAF14 suppresses taf2ts alleles is characterized, shedding light on how Taf2-Taf14 interaction contributes to TFIID complex organization and identifying a potential role for Taf14 in mediating T FIID-chromatin interactions.

TL;DR: It is shown that Mcm1 and Rap1 have the inherent ability to cooperatively activate transcription through contacts with the general transcription factor TFIID, which can account for a pattern of parallel evolution involving the fixation of hundreds of substitutions at a genomic scale.

TL;DR: In this paper , the authors determined the molecular and structural basis by which the YEATS and ET domains of Taf14 bind to the C-terminal tail of the Taf2 and identified a unique DNA-binding activity of the linker region connecting the two domains.

TL;DR: It is shown that Mcm1 and Rap1 have the inherent ability to cooperatively activate transcription through contacts with the general transcription factor TFIID, which can account for a pattern of parallel evolution involving the fixation of hundreds of substitutions at a genomic scale.