F
Friedrich Feuerhake
Researcher at Hannover Medical School
Publications - 118
Citations - 5501
Friedrich Feuerhake is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Digital pathology & Medicine. The author has an hindex of 25, co-authored 103 publications receiving 4695 citations. Previous affiliations of Friedrich Feuerhake include University Medical Center Freiburg & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy
Carola Ries,Michael A. Cannarile,Sabine Hoves,Jörg Benz,Katharina Wartha,Valeria Runza,Flora Rey-Giraud,Leon P. Pradel,Friedrich Feuerhake,Irina Klaman,Tobin Jones,Ute Jucknischke,Stefan Scheiblich,Klaus Kaluza,Ingo H. Gorr,Antje Walz,Keelara Abiraj,Philippe A. Cassier,Antonio Sica,Carlos Gomez-Roca,Karin E. de Visser,Antoine Italiano,Christophe Le Tourneau,Jean-Pierre Delord,Hyam I. Levitsky,Jean-Yves Blay,Dominik Rüttinger +26 more
TL;DR: Administration of RG7155 to patients led to striking reductions of CSF-1R(+)CD163(+) macrophages in tumor tissues, which translated into clinical objective responses in diffuse-type giant cell tumor (Dt-GCT) patients.
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Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
Stefano Monti,Kerry J. Savage,Jeffery L. Kutok,Friedrich Feuerhake,Paul J. Kurtin,Martin C. Mihm,Bingyan Wu,Laura Pasqualucci,Donna Neuberg,Ricardo C.T. Aguiar,Paola Dal Cin,Christine Ladd,Geraldine S. Pinkus,Gilles Salles,Nancy L. Harris,Riccardo Dalla-Favera,Thomas M. Habermann,Jon C. Aster,Todd R. Golub,Todd R. Golub,Margaret A. Shipp +20 more
TL;DR: Tumor microenvironment and host inflammatory response as defining features in DLBCL are identified and rational treatment targets in specificDLBCL subsets are suggested.
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The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma
Kerry J. Savage,Stefano Monti,Jeffery L. Kutok,Giorgio Cattoretti,Donna Neuberg,Laurence de Leval,Paul J. Kurtin,Paola Dal Cin,Christine Ladd,Friedrich Feuerhake,Ricardo C.T. Aguiar,Sigui Li,Gilles Salles,Françoise Berger,Wen Jing,Geraldine S. Pinkus,Thomas M. Habermann,Riccardo Dalla-Favera,Nancy L. Harris,Jon C. Aster,Todd R. Golub,Margaret A. Shipp +21 more
TL;DR: A molecular link between MLBCL and cHL and a shared survival pathway is identified and a classifier of these diseases is developed.
Journal ArticleDOI
Targetable genetic features of primary testicular and primary central nervous system lymphomas
Bjoern Chapuy,Margaretha G.M. Roemer,Margaretha G.M. Roemer,Chip Stewart,Yuxiang Tan,Ryan Abo,Liye Zhang,Andrew Dunford,David Meredith,Aaron R. Thorner,Ekaterina S. Jordanova,Gang Liu,Friedrich Feuerhake,Matthew D. Ducar,Gerald Illerhaus,Daniel Gusenleitner,Erica Linden,Heather Sun,Heather Homer,Miyuki Aono,Geraldine S. Pinkus,Azra H. Ligon,Keith L. Ligon,Judith A. Ferry,Gordon J. Freeman,Paul Van Hummelen,Todd R. Golub,Todd R. Golub,Gad Getz,Gad Getz,Scott J. Rodig,Daphne de Jong,Stefano Monti,Margaret A. Shipp +33 more
TL;DR: These studies identify unique combinations of genetic alterations in discrete LBCL subtypes and subtype-selective bases for targeted therapy and characterize their recurrent somatic mutations, chromosomal rearrangements, copy number alterations (CNAs), and associated driver genes.
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High-Dose Chemotherapy With Autologous Stem-Cell Transplantation and Hyperfractionated Radiotherapy As First-Line Treatment of Primary CNS Lymphoma
Gerald Illerhaus,Reinhard Marks,Gabriele Ihorst,Roland Guttenberger,Christoph B. Ostertag,Günther Derigs,Norbert Frickhofen,Friedrich Feuerhake,Benedikt Volk,Jürgen Finke +9 more
TL;DR: Sequential systemic methotrexate and AraC and thiotepa followed by HDT plus ASCT and hyperfractionated WBRT is very effective with little toxicity as initial therapy for PCNSL.