Jörg H. Leupold

TL;DR: This is the first study to show that Pdcd4 is negatively regulated by miR-21, and the first report to demonstrate that mi R-21 induces invasion/intravasation/metastasis.

TL;DR: Data suggest Pdcd4 as a new negative regulator of intravasation, and qas the invasion-related gene u-PAR, the first study to implicate PdCD4 regulation of gene expression via Sp1/Sp3.

TL;DR: This article dissects the contribution of microRNAs to EMT and analyzes the molecular basis for their roles in this cellular process, and emphasizes their interaction with core transcription factors like the zinc finger enhancer (E)-box binding homeobox), Snail and Twist families as well as some pluripotency transcription factors.

TL;DR: The CASC9:HNRNPL complex is identified as a clinically relevant viability‐associated lncRNA/protein complex which affects AKT signaling and DNA damage sensing in HCC.

TL;DR: This review summarizes and discusses the latest findings on how mi RNAs have become therapeutic targets of diverse synthetic antagonists, how novel endogenous regulators of miRNAs such as ceRNAs or pseudogenes could emerge as therapeutics scavenging oncogenic miRNA-regulators and how miRNAAs themselves are already, and will increasingly be, used as therapeuers.