M
Matthias Groß
Researcher at German Cancer Research Center
Publications - 12
Citations - 2355
Matthias Groß is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Regulation of gene expression & RNA interference. The author has an hindex of 10, co-authored 12 publications receiving 1931 citations. Previous affiliations of Matthias Groß include University Hospital Heidelberg & Heidelberg University.
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Journal ArticleDOI
The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Tony Gutschner,Monika Hämmerle,Moritz Eißmann,Jeff Hsu,Youngsoo Kim,Gene Hung,Alexey S. Revenko,Gayatri Arun,Marion Stentrup,Matthias Groß,Martin Zörnig,A. Robert MacLeod,David L. Spector,Sven Diederichs +13 more
TL;DR: A loss-of-function model unravels the active function of MALAT1 as a regulator of gene expression governing hallmarks of lung cancer metastasis with this ncRNA serving as both predictive marker and therapeutic target.
Journal ArticleDOI
Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development.
Moritz Eißmann,Tony Gutschner,Monika Hämmerle,Stefan Günther,Maïwen Caudron-Herger,Matthias Groß,Peter Schirmacher,Karsten Rippe,Thomas Braun,Martin Zörnig,Sven Diederichs +10 more
TL;DR: Loss of the abundant nuclear long ncRNA MALAT1 is compatible with cell viability and normal development and genetic loss in a knockout mouse model did not give rise to any obvious phenotype or histological abnormalities in Malat1-null compared with wild-type animals.
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Challenges of CRISPR/Cas9 applications for long non-coding RNA genes.
Ashish Goyal,Ashish Goyal,Ksenia Myacheva,Matthias Groß,Matthias Groß,Marcel Klingenberg,Marcel Klingenberg,Marcel Klingenberg,Berta Duran Arqué,Sven Diederichs +9 more
TL;DR: It is found that despite the advantages of CRISPR/Cas9 to modulate expression bidirectionally and in cis, approaches based on ASOs or siPOOLs may be the better choice to target specifically the transcript from complex loci.
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A pan-cancer analysis of synonymous mutations.
Yogita Sharma,Milad Miladi,Sandeep Dukare,Karine Boulay,Maïwen Caudron-Herger,Matthias Groß,Rolf Backofen,Sven Diederichs +7 more
TL;DR: A catalogue of synonymous mutations in cancer and characterise their properties is presented, indicating that single point mutations can have a relevant impact on expression as well as on mRNA secondary structure.
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The Long Noncoding RNA Cancer Susceptibility 9 and RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein L Form a Complex and Coregulate Genes Linked to AKT Signaling
Marcel Klingenberg,Matthias Groß,Matthias Groß,Ashish Goyal,Maria Polycarpou-Schwarz,Thilo Miersch,Anne Sophie Ernst,Jörg H. Leupold,Nitin Patil,Uwe Warnken,Heike Allgayer,Thomas Longerich,Peter Schirmacher,Michael Boutros,Sven Diederichs +14 more
TL;DR: The CASC9:HNRNPL complex is identified as a clinically relevant viability‐associated lncRNA/protein complex which affects AKT signaling and DNA damage sensing in HCC.